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Yeast Fitness
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YMR300C / ADE4



Section 1: Phenotypes.
Gene-drug relationships for YMR300C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR300C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ADE4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
clotrimazole 1 uM 5.40235 1.0664e-06
lapachol 500 uM 4.86243 6.6866e-06
doxorubicin 62.5 uM 4.23499 5.2741e-05
cantharidin 250 uM 4.21369 0.025985
cantharidin 250 uM 4.12639 0.027008
atorvastatin 125 uM 4.06115 9.185e-05
cantharidin 250 uM 4.00978 0.028468
cantharidin 250 uM 3.92554 0.029595
cantharidin 250 uM 3.89765 0.029983
latrunculin 6.25 uM 3.81734 0.00075812

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ADE4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
rapamycin 9 nM 17.2047 0.0016807
synthetic complete for BY4743 0 15.9148 0.0019625
synthetic complete for BY4743 0 15.3738 0.0002989
minimal media 0 13.1606 6.1031e-08
synthetic complete for BY4743 0 11.1036 5.3436e-06
minimal media 0 10.9125 1.669e-11
synthetic complete for BY4743 0 10.5828 7.3549e-06
synthetic complete for BY4743 0 9.8242 1.2022e-05
rapamycin 9 nM 9.52255 0.0054244
synthetic complete for BY4743 0 9.24389 0.00038068

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR300C

Top 10 functional gene interactors with YMR300C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ADE4 by heterozygous co-sensitivity:

Query Interactor Correlation
ADE4 YMR290W-A 0.57603
ADE4 ISC1 0.46791
ADE4 IRC10 0.46394
ADE4 DBP5 0.45514
ADE4 DST1 0.45479
ADE4 MTF2 0.45233
ADE4 GPR1 0.4488
ADE4 KRE27 0.44845
ADE4 GLN3 0.4392
ADE4 GPA2 0.43393

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ADE4 by homozygous co-sensitivity:

Query Interactor Correlation
ADE4 ADE6 0.63193
ADE4 ADE8 0.51838
ADE4 ADE5,7 0.47969
ADE4 SHM2 0.39601
ADE4 ADE3 0.38978
ADE4 BAS1 0.38637
ADE4 ARG5,6 0.38303
ADE4 ARG1 0.37369
ADE4 YER068C-A 0.37069
ADE4 ACO2 0.36819

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None




External information about YMR300C

Other databases:

Visit YMR300C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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