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Yeast Fitness

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YMR296C / LCB1

Section 1: Phenotypes.
Gene-drug relationships for YMR296C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR296C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for LCB1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 32.3016 < 1e-12
benomyl 6.9 uM 28.6443 4.8577e-07
benomyl 13.8 uM 21.2782 2.1251e-06
aphidicolin glycinate 125 uM 20.6163 < 1e-12
latrunculin 3.91 uM 19.6273 < 1e-12
benfluorex hydrochloride 250 uM 18.3494 < 1e-12
drofenine hydrochloride 750 uM 18.1162 < 1e-12
caspofungin 10 nM 18.0163 < 1e-12
clozapine 500 uM 17.2377 < 1e-12
cocl2 1250 uM 16.8145 < 1e-12

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YMR296C

Top 10 functional gene interactors with YMR296C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with LCB1 by heterozygous co-sensitivity:

Query Interactor Correlation
LCB1 SLM5 0.8597
LCB1 CTP1 0.85147
LCB1 IMG2 0.83397
LCB1 MAL33 0.81453
LCB1 YCR076C 0.80762
LCB1 YBR284W 0.80709
LCB1 RPS14A 0.80325
LCB1 ATG15 0.79614
LCB1 FEN1 0.79331
LCB1 FEN2 0.793

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YMR296C

Other databases:

Visit YMR296C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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