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Yeast Fitness
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YMR284W / YKU70



Section 1: Phenotypes.
Gene-drug relationships for YMR284W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR284W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YKU70 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
alverine citrate 500 uM 12.1861 0.0033333
itraconazole 17.7 uM 6.03845 1.1771e-07
lapachol 500 uM 3.91381 0.00014594
fenpropimorph 8 nM 3.31559 0.00088419
no drug minimal media 0 3.2502 0.008731
fluconazole 130.6 uM 3.0073 0.0021117
fenpropimorph 4.7 uM 2.97573 0.0023028
benzyl benzoate 1000 uM 2.81009 0.0035986
no drug minimal media 0 2.49889 0.023299
tunicamycin 0.15 uM 2.3779 0.031665

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YKU70 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
phosphatase inhibitor 3 uM 13.9462 < 1e-12
fecl4 5000 uM 13.8942 < 1e-12
synthetic complete for BY4743 0 9.82512 9.3015e-05
synthetic complete for BY4743 0 8.99923 2.134e-05
mncl2 1 mM 8.8647 1.1617e-10
37 degrees C 0 8.68974 1.8124e-09
synthetic complete for BY4743 0 8.15153 0.00061631
phosphatase inhibitor 2 uM 7.59176 4.0357e-09
synthetic complete for BY4743 0 7.52251 0.0024344
mncl2 1 mM 7.38928 7.2196e-09

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR284W

Top 10 functional gene interactors with YMR284W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YKU70 by heterozygous co-sensitivity:

Query Interactor Correlation
YKU70 YJR079W 0.67271
YKU70 YHL037C 0.56281
YKU70 YPR096C 0.54075
YKU70 ADE2 0.53037
YKU70 OTU2 0.51621
YKU70 RPL1A 0.50913
YKU70 FRE3 0.50001
YKU70 MLP1 0.49926
YKU70 PDX3 0.48759
YKU70 YPR063C 0.47412

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YKU70 by homozygous co-sensitivity:

Query Interactor Correlation
YKU70 YKU80 0.49701
YKU70 YHI9 0.433
YKU70 GOT1 0.42407
YKU70 ECM2 0.42166
YKU70 TAN1 0.39917
YKU70 YKR077W 0.39777
YKU70 SSF2 0.39195
YKU70 LEU4 0.39084
YKU70 VTC2 0.38591
YKU70 THI22 0.38572

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None




External information about YMR284W

Other databases:

Visit YMR284W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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