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YMR272C / SCS7



Section 1: Phenotypes.
Gene-drug relationships for YMR272C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR272C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SCS7 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
lapachol 500 uM 12.207 < 1e-12
dihydromotuporamine C 15 uM 11.7386 < 1e-12
dna protein kinase inhibitor 0 10.0655 9.6608e-12
itraconazole 4.4 uM 9.09895 4.7031e-12
nacl 700 mM 6.87123 4.4731e-08
dyclonine 500 uM 6.80688 9.4217e-06
aureobasidin a 0.02 ug/ml 6.30339 2.2614e-07
itraconazole 17.7 uM 6.10557 9.3142e-08
methotrexate 500 uM 5.64684 1.5123e-06
5-fluorouracil 76.8 uM 5.57061 1.8877e-06

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SCS7 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 42.3173 0.00027898
synthetic complete for BY4743 0 37.8158 0.00034927
synthetic complete for BY4743 0 28.556 3.2273e-11
synthetic complete for BY4743 0 23.8563 1.9027e-10
sorbitol 1.5e+06 uM 21.7016 4.8231e-10
ph8 0 18.9052 < 1e-12
synthetic complete for BY4743 0 17.6658 5.331e-06
minimal media 0 17.6536 < 1e-12
sorbitol 1.5e+06 uM 17.4519 < 1e-12
minimal media 0 17.0924 4.9549e-09

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR272C

Top 10 functional gene interactors with YMR272C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SCS7 by heterozygous co-sensitivity:

Query Interactor Correlation
SCS7 YAL042C-A 0.51455
SCS7 BUD22 0.47478
SCS7 YKL044W 0.45555
SCS7 YGR093W 0.44162
SCS7 IOC4 0.43335
SCS7 STR2 0.42912
SCS7 ERP2 0.42876
SCS7 FRT2 0.4227
SCS7 YOL013W-A 0.41346
SCS7 YAL049C 0.41346

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SCS7 by homozygous co-sensitivity:

Query Interactor Correlation
SCS7 ECM30 0.53559
SCS7 LYS14 0.49967
SCS7 LYS12 0.48508
SCS7 SDT1 0.43645
SCS7 YMR122C 0.4305
SCS7 STP2 0.42487
SCS7 YCL046W 0.42093
SCS7 INO4 0.41355
SCS7 CRS5 0.40936
SCS7 LYS4 0.40873

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YMR272C

Other databases:

Visit YMR272C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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