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YMR194W / RPL36A



Section 1: Phenotypes.
Gene-drug relationships for YMR194W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR194W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPL36A Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
hydroxyurea 100000 uM 7.33064 1.2922e-09
clofoctol 1000 uM 6.82904 7.4284e-09
latrunculin 6.25 uM 5.22669 4.1547e-05
propiomazine maleate 500 uM 4.7501 9.7387e-06
itraconazole 4.4 uM 4.08791 8.4379e-05
mecysteine hydrochloride 62.5 uM 3.9479 0.00013119
hydroxyurea 50000 uM 3.69464 0.00028678
econazole nitrate 0.24 uM 3.62584 0.00035328
tolnaftate 125 uM 3.49519 0.00052234
pyrimethamine 1000 uM 3.47066 0.00056171

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPL36A Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 10.8788 1.2032e-09
sorbitol 1.5e+06 uM 3.9784 0.0013038
rapamycin 9 nM 2.76403 0.05488
rapamycin 9 nM 2.71496 0.036429
cisplatin 31.25 uM 2.64092 0.0069012
cisplatin 31.25 uM 2.60502 0.0074974
cycloheximide 32.3 uM 2.53603 0.0079873
chlorambucil 250 uM 2.26945 0.01485
synthetic complete for BY4743 0 2.24711 0.024208
cuso4 10000 uM 2.19911 0.017386

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR194W

Top 10 functional gene interactors with YMR194W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPL36A by heterozygous co-sensitivity:

Query Interactor Correlation
RPL36A RPL35B 0.47676
RPL36A MRE11 0.44203
RPL36A OPI11 0.44009
RPL36A HIS1 0.43704
RPL36A YJR079W 0.43122
RPL36A RPL34A 0.42954
RPL36A YHI9 0.42853
RPL36A MIG3 0.42161
RPL36A GAS4 0.41683
RPL36A IMP1 0.41543

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with RPL36A by homozygous co-sensitivity:

Query Interactor Correlation
RPL36A RPL33B 0.77296
RPL36A RPL27B 0.71763
RPL36A RPP2A 0.71225
RPL36A RPL2A 0.6839
RPL36A YDL063C 0.67133
RPL36A RPL17B 0.66691
RPL36A ARX1 0.66644
RPL36A RPL8B 0.65742
RPL36A RPL31B 0.65104
RPL36A NOP12 0.64023

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YMR194W

Other databases:

Visit YMR194W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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