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Yeast Fitness
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YMR194C-A / YMR194C-A



Section 1: Phenotypes.
Gene-drug relationships for YMR194C-A
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR194C-A deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YMR194C-A Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 8.30168 8.7281e-10
tomatine 62.5 uM 4.50893 2.1645e-05
sodium sulfate 625 uM 3.43367 0.00083272
itraconazole 17.7 uM 3.14032 0.0014582
no drug minimal media 0 3.13687 0.012879
lapachol 1000 uM 3.08992 0.0016795
itraconazole 8.8 uM 2.94594 0.0024979
clotrimazole 1 uM 2.78312 0.0038648
clozapine 500 uM 2.77924 0.0039046
5-fluorocytosine 15.6 uM 2.75654 0.0041449

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YMR194C-A Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 28.2688 4.8592e-05
cuso4 12000 uM 15.1734 < 1e-12
methotrexate 250 uM 9.13446 6.7434e-10
nocodazole 10 ug/ml 7.35166 3.9958e-07
sorbitol 1.5e+06 uM 7.27137 5.0507e-08
ph8 0 7.01008 9.5901e-08
mechlorethamine 62.5 uM 6.72611 0.010699
myriocin 0.2 ug/ml 6.13666 4.2645e-06
minimal media 0 5.92122 1.5086e-06
zncl2 1875 uM 5.1243 5.9253e-06

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR194C-A

Top 10 functional gene interactors with YMR194C-A. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YMR194C-A by heterozygous co-sensitivity:

Query Interactor Correlation
YMR194C-A GYP5 0.63348
YMR194C-A IKS1 0.58357
YMR194C-A SRT1 0.57888
YMR194C-A YGL176C 0.57592
YMR194C-A YOL083W 0.57486
YMR194C-A YNL100W 0.56799
YMR194C-A YOL048C 0.56756
YMR194C-A STE13 0.56579
YMR194C-A FIT2 0.56287
YMR194C-A YLL059C 0.56109

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YMR194C-A by homozygous co-sensitivity:

Query Interactor Correlation
YMR194C-A YHR182W 0.51773
YMR194C-A CAM1 0.49388
YMR194C-A MCH1 0.48586
YMR194C-A YGR053C 0.48283
YMR194C-A CRS5 0.45571
YMR194C-A YDR215C 0.44718
YMR194C-A MF(ALPHA)2 0.44489
YMR194C-A LIF1 0.44011
YMR194C-A TIF4632 0.43869
YMR194C-A MUP3 0.43417

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YMR194C-A

Other databases:

Visit YMR194C-A in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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