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Yeast Fitness
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YMR186W / HSC82



Section 1: Phenotypes.
Gene-drug relationships for YMR186W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR186W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for HSC82 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
clotrimazole 1 uM 7.04498 3.4944e-09
itraconazole 4.4 uM 5.09186 3.0811e-06
5-fluorouracil 19.2 uM 5.0458 5.9667e-05
fluconazole 65.3 uM 4.46396 2.5084e-05
tryptanthrin 250 uM 3.96348 0.00019402
tunicamycin 0.15 uM 3.91955 0.0055935
drofenine hydrochloride 750 uM 3.86147 0.00017175
wiskostatin 29 uM 3.81114 0.00029677
atorvastatin 125 uM 3.80365 0.00020537
5-fluorocytosine 15.6 uM 3.783 0.00021885

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for HSC82 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 24.3534 < 1e-12
rapamycin 6 nM 20.1557 < 1e-12
methotrexate 250 uM 16.6462 < 1e-12
licl 100 mM 13.9539 2.1467e-11
rapamycin 4.88 nM 13.023 < 1e-12
thiabendazole 250 uM 10.2985 5.7254e-11
licl 150 mM 10.2204 3.3278e-12
licl 150 mM 8.41894 3.9348e-10
yp glycerol 0 8.28764 4.3151e-06
methotrexate 250 uM 8.20434 5.4938e-09

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR186W

Top 10 functional gene interactors with YMR186W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with HSC82 by heterozygous co-sensitivity:

Query Interactor Correlation
HSC82 RRM3 0.48075
HSC82 YMR258C 0.43774
HSC82 FSH2 0.4347
HSC82 MRE11 0.43076
HSC82 ATG16 0.42828
HSC82 ARN1 0.4204
HSC82 YER087C-A 0.41247
HSC82 YPR096C 0.41153
HSC82 GUT1 0.41125
HSC82 NDE1 0.41061

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with HSC82 by homozygous co-sensitivity:

Query Interactor Correlation
HSC82 AVL9 0.52772
HSC82 BMH1 0.51936
HSC82 BMH2 0.51649
HSC82 YAP1802 0.5156
HSC82 YGR242W 0.50549
HSC82 YOR053W 0.47862
HSC82 ABP1 0.47001
HSC82 DPH2 0.46642
HSC82 YNL140C 0.45758
HSC82 DAP2 0.44919

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YMR186W

Other databases:

Visit YMR186W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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