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Yeast Fitness
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YMR169C / ALD3



Section 1: Phenotypes.
Gene-drug relationships for YMR169C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR169C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ALD3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 6.45797 0.00066256
monastrol 100 uM 5.75257 1.1122e-06
papuamide b 0.7 ug/ml 4.45603 4.7896e-05
methotrexate 500 uM 4.36344 6.245e-05
methotrexate 125 uM 4.31652 7.1413e-05
no drug minimal media 0 4.23355 0.0041101
5-fluorouracil 76.8 uM 3.96083 0.00019547
methotrexate 250 uM 3.89687 0.00023376
no drug minimal media 0 3.89181 0.0057519
AG 1478 (Biomol) 100 uM 3.45504 0.0007862

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ALD3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nocodazole 10 ug/ml 6.51757 1.9869e-06
mitomycin c 1000 uM 6.03265 1.1317e-06
nocodazole 10 ug/ml 5.08633 3.8524e-05
mitomycin c 1000 uM 4.44025 4.51e-05
l-dopa 12.5 ug/ml 4.43544 4.574e-05
nacl 1000 uM 4.30176 0.00077856
aureobasidin a 0.02 ug/ml 3.9516 0.00046772
nacl 1000 uM 3.9248 0.0014221
allyl disulfide 0.06 % 3.67314 0.00040864
synthetic complete for BY4743 0 3.46428 0.0030395

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR169C

Top 10 functional gene interactors with YMR169C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ALD3 by heterozygous co-sensitivity:

Query Interactor Correlation
ALD3 YDR066C 0.41904
ALD3 YHL039W 0.40887
ALD3 PST1 0.40212
ALD3 YDR286C 0.40164
ALD3 ANB1 0.39839
ALD3 MNT4 0.3956
ALD3 TOK1 0.38841
ALD3 CIS3 0.38839
ALD3 MPC54 0.38638
ALD3 YAL066W 0.37856

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ALD3 by homozygous co-sensitivity:

Query Interactor Correlation
ALD3 HIS4 0.39644
ALD3 YHR202W 0.39291
ALD3 YDC1 0.39236
ALD3 MSC2 0.37711
ALD3 TFP3 0.37639
ALD3 YBR032W 0.36869
ALD3 SMA1 0.35833
ALD3 YAL049C 0.35247
ALD3 FMP42 0.34838
ALD3 GSC2 0.3417

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YMR169C

Other databases:

Visit YMR169C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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