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Yeast Fitness
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YMR159C / ATG16



Section 1: Phenotypes.
Gene-drug relationships for YMR159C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR159C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ATG16 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 6.25 uM 9.00109 5.8161e-08
caspofungin 10 nM 5.91131 1.8328e-07
itraconazole 4.4 uM 5.90512 1.8726e-07
methotrexate 250 uM 4.91886 1.2577e-05
itraconazole 17.7 uM 4.5681 1.7814e-05
itraconazole 17.7 uM 4.32879 3.8962e-05
methotrexate 250 uM 4.17213 0.00010771
methotrexate 500 uM 3.71462 0.00026984
methotrexate 500 uM 3.57363 0.00041336
fluconazole 130.6 uM 3.54531 0.00044992

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ATG16 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nocodazole 10 ug/ml 19.2011 < 1e-12
methotrexate 250 uM 11.495 5.4021e-12
mitomycin c 1000 uM 7.85154 1.2544e-08
ph4 8 7.58071 4.1653e-09
ph4 8 7.11791 1.5846e-08
cadmium chloride 7.81 uM 7.02143 2.0991e-08
acriflavinium hydrochloride 250 uM 6.43192 4.0783e-07
synthetic complete for BY4743 0 5.93095 0.0047898
mechlorethamine 62.5 uM 4.87819 2.3174e-05
k2cr2o7 125 uM 4.47542 4.0673e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR159C

Top 10 functional gene interactors with YMR159C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ATG16 by heterozygous co-sensitivity:

Query Interactor Correlation
ATG16 YMR254C 0.46713
ATG16 YJL045W 0.45597
ATG16 ECM34 0.44491
ATG16 YMR187C 0.43576
ATG16 YER079W 0.43447
ATG16 HSC82 0.42828
ATG16 YOR021C 0.4267
ATG16 ARN1 0.42601
ATG16 PET127 0.42377
ATG16 YEN1 0.42078

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ATG16 by homozygous co-sensitivity:

Query Interactor Correlation
ATG16 HSP26 0.70911
ATG16 SOL1 0.66321
ATG16 GUT2 0.62659
ATG16 OPT2 0.61625
ATG16 SFT2 0.61218
ATG16 SDP1 0.61203
ATG16 BNA4 0.59881
ATG16 IRC20 0.58325
ATG16 SAL1 0.58145
ATG16 GMH1 0.56852

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None




External information about YMR159C

Other databases:

Visit YMR159C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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