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Yeast Fitness
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YMR138W / CIN4



Section 1: Phenotypes.
Gene-drug relationships for YMR138W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR138W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CIN4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorocytosine 15.6 uM 6.34809 3.9929e-08
nacl 700 mM 6.04607 4.7499e-07
fenpropimorph 2.3 uM 5.63525 5.4908e-05
itraconazole 4.4 uM 5.52677 6.9483e-07
itraconazole 17.7 uM 5.43984 9.3744e-07
itraconazole 17.7 uM 5.10528 2.9438e-06
mechlorethamine 500 uM 4.94073 5.138e-06
mechlorethamine 500 uM 4.92363 5.4428e-06
5-fluorouridine 95 uM 4.68155 1.2236e-05
bithionol 75 uM 4.54859 1.8997e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for CIN4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
benomyl 10 ug/ml 70.5674 3.1356e-06
nocodazole 10 ug/ml 23.946 < 1e-12
phosphatase inhibitor 3 uM 20.9887 < 1e-12
mitomycin c 1000 uM 15.6457 < 1e-12
benomyl 10 ug/ml 13.5527 3.4756e-11
nocodazole 10 ug/ml 13.4268 4.0524e-11
sodium sulfate 625 uM 11.8896 < 1e-12
chemdiv 275 62 uM 9.83173 8.9913e-12
cocl2 1250 uM 9.56612 1.7938e-11
benomyl 10 ug/ml 8.57014 4.535e-08

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR138W

Top 10 functional gene interactors with YMR138W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with CIN4 by heterozygous co-sensitivity:

Query Interactor Correlation
CIN4 ARG5,6 0.47053
CIN4 YBR064W 0.43159
CIN4 SET3 0.41595
CIN4 INO4 0.40612
CIN4 DAN1 0.40471
CIN4 CYT1 0.4046
CIN4 SPE4 0.39614
CIN4 TLG1 0.39099
CIN4 GPT2 0.38917
CIN4 YMR291W 0.38547

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with CIN4 by homozygous co-sensitivity:

Query Interactor Correlation
CIN4 EUG1 0.54932
CIN4 PET100 0.53612
CIN4 MRPS16 0.52594
CIN4 CIN1 0.51568
CIN4 BUB2 0.5125
CIN4 MIP1 0.50644
CIN4 PAC2 0.50413
CIN4 YJL022W 0.49158
CIN4 RSM22 0.46778
CIN4 MST1 0.4523

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:




External information about YMR138W

Other databases:

Visit YMR138W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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