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Yeast Fitness
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YMR133W / REC114



Section 1: Phenotypes.
Gene-drug relationships for YMR133W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR133W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for REC114 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
bithionol 75 uM 5.91094 1.8351e-07
5-fluorouracil 76.8 uM 5.07452 8.0003e-06
progesterone 250 uM 3.97155 0.00012182
dyclonine 500 uM 3.58851 0.0018618
bcnu 62.5 uM 3.136 0.0018296
5-fluorouracil 38.4 uM 2.70565 0.0054182
phenanthroline monohydrochloride 62.5 uM 2.43421 0.010342
wiskostatin 29 uM 2.2563 0.015509
methotrexate 125 uM 2.21352 0.017056
fenpropimorph 2.3 uM 2.1394 0.026824

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for REC114 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nocodazole 10 ug/ml 9.55513 8.9533e-09
synthetic complete for BY4743 0 2.66983 0.022179
synthetic complete for BY4743 0 1.84616 0.053685
synthetic complete for BY4743 0 1.59865 0.092572
latrunculin 0.78 uM 1.51281 0.11377
latrunculin 3 uM 1.49489 0.076134
latrunculin 0.78 uM 1.48198 0.077821
mpp+ 250 ug/ml 1.41083 0.083689
l-dopa 12.5 ug/ml 1.32724 0.096636
methotrexate 500 uM 1.32641 0.10064

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR133W

Top 10 functional gene interactors with YMR133W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with REC114 by heterozygous co-sensitivity:

Query Interactor Correlation
REC114 ATR1 0.72084
REC114 ALG5 0.70669
REC114 VPS15 0.65672
REC114 PPR1 0.63089
REC114 YDL057W 0.62774
REC114 SVS1 0.62469
REC114 SOL4 0.62067
REC114 YKL047W 0.60954
REC114 PXA2 0.60862
REC114 YJL007C 0.60326

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with REC114 by homozygous co-sensitivity:

Query Interactor Correlation
REC114 TOS2 0.86763
REC114 YOR111W 0.86224
REC114 ISU2 0.85553
REC114 MAL12 0.84265
REC114 YPR117W 0.83943
REC114 YOL163W 0.83769
REC114 YOR289W 0.82458
REC114 HOS3 0.81622
REC114 YCL023C 0.81363
REC114 YKL151C 0.81048

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YMR133W

Other databases:

Visit YMR133W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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