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YMR109W / MYO5



Section 1: Phenotypes.
Gene-drug relationships for YMR109W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR109W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MYO5 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
caspofungin 10 nM 16.2118 < 1e-12
caspofungin 10 nM 15.1163 < 1e-12
trichostatin A 3.91 uM 6.8031 5.4252e-08
miconazole 0.2 uM 6.66191 2.7311e-06
metergoline 250 uM 6.15349 7.8799e-08
caspofungin 10 nM 5.46355 8.6398e-07
cisplatin 125 uM 5.25637 1.7589e-06
terreic acid 1000 uM 4.53965 3.7662e-05
doxorubicin 62.5 uM 4.50243 2.2111e-05
miconazole 25 nM 4.10996 7.867e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for MYO5 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nystatin 10 uM 22.0958 4.0422e-10
nystatin 10 uM 20.1186 1.0128e-09
wiskostatin 29 uM 19.4133 < 1e-12
paraquat 5000 uM 18.7702 < 1e-12
sodium fluoride 20000 uM 18.3573 < 1e-12
paraquat 5000 uM 17.4808 < 1e-12
sodium fluoride 20000 uM 14.8282 < 1e-12
rapamycin 9 nM 14.4337 0.00036046
mitomycin c 1000 uM 13.7419 < 1e-12
nystatin 10 uM 13.4458 8.8279e-11

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR109W

Top 10 functional gene interactors with YMR109W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MYO5 by heterozygous co-sensitivity:

Query Interactor Correlation
MYO5 YKU80 0.57074
MYO5 ADH4 0.45969
MYO5 ADE17 0.4493
MYO5 YMR111C 0.44065
MYO5 CLB3 0.43595
MYO5 HFD1 0.43087
MYO5 ECM34 0.42904
MYO5 KTR7 0.42363
MYO5 MID1 0.42053
MYO5 PUF2 0.4179

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with MYO5 by homozygous co-sensitivity:

Query Interactor Correlation
MYO5 FSH1 0.59809
MYO5 PRM8 0.54063
MYO5 SPH1 0.53995
MYO5 AVT7 0.52522
MYO5 RSF2 0.52515
MYO5 RNP1 0.5249
MYO5 YER186C 0.52037
MYO5 CSI2 0.50759
MYO5 YHR022C 0.50516
MYO5 YPR014C 0.50452

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:




External information about YMR109W

Other databases:

Visit YMR109W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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