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Yeast Fitness
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YMR070W / MOT3



Section 1: Phenotypes.
Gene-drug relationships for YMR070W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR070W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MOT3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
tomatine 62.5 uM 5.45999 8.7463e-07
k2cr2o7 6.25 uM 5.12132 6.9819e-06
bisphenol s 100 uM 4.69868 1.1558e-05
hydroxyurea 100000 uM 4.21213 5.6761e-05
mitomycin c 1000 uM 4.17426 6.4083e-05
fluconazole 32.6 uM 4.14007 7.1478e-05
floxuridine 80000 uM 3.68182 0.00029819
5-fluorouridine 95 uM 3.63291 0.00034582
5-fluorouracil 38.5 uM 3.54696 0.00044771
miconazole 100 uM 3.34721 0.00080673

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for MOT3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 25.6125 9.4502e-11
synthetic complete for BY4743 0 25.1435 1.1339e-10
allyl disulfide 0.06 % 24.6277 < 1e-12
mitomycin c 1000 uM 23.1559 < 1e-12
rapamycin 6 nM 22.1201 < 1e-12
rapamycin 4.88 nM 20.4462 < 1e-12
zncl2 1875 uM 14.2092 < 1e-12
wiskostatin 29 uM 13.17 < 1e-12
cantharidin 200 uM 12.7205 < 1e-12
latrunculin 0.78 uM 11.6241 0.0036598

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR070W

Top 10 functional gene interactors with YMR070W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MOT3 by heterozygous co-sensitivity:

Query Interactor Correlation
MOT3 YPL229W 0.44498
MOT3 NHP6A 0.38943
MOT3 YGL217C 0.3893
MOT3 TGL3 0.37639
MOT3 SXM1 0.37021
MOT3 MDH3 0.3573
MOT3 MUD1 0.35172
MOT3 YPL056C 0.34324
MOT3 MET16 0.34086
MOT3 YKL151C 0.33582

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with MOT3 by homozygous co-sensitivity:

Query Interactor Correlation
MOT3 LAP3 0.74975
MOT3 PBP1 0.54006
MOT3 RPL34B 0.5236
MOT3 PTC6 0.50866
MOT3 YOL159C 0.4818
MOT3 UBP13 0.47391
MOT3 YMR007W 0.46823
MOT3 GZF3 0.46463
MOT3 SNG1 0.4632
MOT3 YNL190W 0.46029

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None




External information about YMR070W

Other databases:

Visit YMR070W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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