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Yeast Fitness
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YMR054W / STV1



Section 1: Phenotypes.
Gene-drug relationships for YMR054W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR054W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for STV1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
trichostatin A 3.91 uM 9.80379 1.8367e-11
dihydromotuporamine C 15 uM 9.62281 2.8792e-11
miconazole 0.2 uM 7.5668 5.6656e-07
caspofungin 10 nM 5.32451 1.393e-06
benztropine 1 uM 5.16645 2.3906e-06
caspofungin 10 nM 4.32165 3.9874e-05
daunorubicin 125 uM 4.1634 6.6347e-05
amphotericin b 10 uM 4.12007 7.6181e-05
doxorubicin 62.5 uM 3.92562 0.00014066
terreic acid 1000 uM 3.60067 0.00052972

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for STV1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 31.4207 1.2527e-11
tryptophan dropout 0 29.9647 2.0041e-11
synthetic complete for BY4743 0 18.4212 2.3937e-09
bisphenol s 100 uM 18.367 < 1e-12
nocodazole 10 ug/ml 17.6668 < 1e-12
bisphenol s 100 uM 16.0166 < 1e-12
bisphenol s 75 uM 12.076 < 1e-12
adenine dropout 0 11.8622 6.0186e-10
synthetic complete for BY4743 400 uM 11.3926 1.1107e-09
mncl2 2 mM 11.2492 < 1e-12

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR054W

Top 10 functional gene interactors with YMR054W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with STV1 by heterozygous co-sensitivity:

Query Interactor Correlation
STV1 AAC1 0.61912
STV1 SCS2 0.57068
STV1 SNF4 0.54989
STV1 BUB2 0.54844
STV1 YGL242C 0.53518
STV1 DSE1 0.5304
STV1 PDA1 0.52493
STV1 FAU1 0.52277
STV1 YER187W 0.51766
STV1 YER119C-A 0.5031

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with STV1 by homozygous co-sensitivity:

Query Interactor Correlation
STV1 ATX1 0.61827
STV1 RAV1 0.60314
STV1 YDR203W 0.60122
STV1 RDS2 0.57811
STV1 YDR271C 0.57064
STV1 RAV2 0.55954
STV1 PPQ1 0.54755
STV1 FRE1 0.54136
STV1 YPL182C 0.52212
STV1 YMR057C 0.50586

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YMR054W

Other databases:

Visit YMR054W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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