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Yeast Fitness
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YMR044W / IOC4



Section 1: Phenotypes.
Gene-drug relationships for YMR044W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR044W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for IOC4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 12.1162 3.3826e-05
dihydromotuporamine C 15 uM 9.45973 4.3333e-11
dna protein kinase inhibitor 0 8.81473 2.2586e-10
drofenine hydrochloride 750 uM 7.92525 1.6633e-10
itraconazole 17.7 uM 7.71492 3.4192e-10
methotrexate 500 uM 7.39345 1.0348e-08
methotrexate 125 uM 6.5921 9.8881e-08
clotrimazole 1 uM 6.14285 8.1781e-08
clozapine 500 uM 5.78863 2.8072e-07
mecysteine hydrochloride 62.5 uM 5.74844 3.2273e-07

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for IOC4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 27.758 5.6795e-07
wiskostatin 29 uM 15.4462 < 1e-12
cadmium chloride 7.81 uM 10.1979 3.5231e-12
minimal media 0 7.62121 3.5099e-07
sorbitol 1.5e+06 uM 7.5319 2.6877e-08
sorbitol 1.5e+06 uM 7.08946 9.0778e-07
thiabendazole 250 uM 7.00513 9.7081e-08
sorbitol 1 M 6.78477 4.1987e-08
allyl disulfide 0.06 % 6.69651 5.4441e-08
synthetic complete for BY4743 0 6.39359 0.00069337

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR044W

Top 10 functional gene interactors with YMR044W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with IOC4 by heterozygous co-sensitivity:

Query Interactor Correlation
IOC4 YAL042C-A 0.7
IOC4 YML018C 0.69987
IOC4 RSF1 0.67044
IOC4 YML047W-A 0.64531
IOC4 PIC2 0.62954
IOC4 BUD22 0.62271
IOC4 AFG1 0.60772
IOC4 SWH1_p 0.60277
IOC4 STR2 0.58039
IOC4 WSC4 0.5709

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with IOC4 by homozygous co-sensitivity:

Query Interactor Correlation
IOC4 YML018C 0.69723
IOC4 YGR201C 0.69331
IOC4 SWH1_p 0.65871
IOC4 YML047W-A 0.63455
IOC4 MVP1 0.63261
IOC4 SPO13 0.63227
IOC4 YPR091C 0.61772
IOC4 PHO89 0.58518
IOC4 CPR1 0.58198
IOC4 IZH4 0.57626

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YMR044W

Other databases:

Visit YMR044W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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