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YML124C / TUB3



Section 1: Phenotypes.
Gene-drug relationships for YML124C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YML124C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TUB3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
thiabendazole 250 uM 39.6169 < 1e-12
sodium sulfate 625 uM 28.1974 < 1e-12
benomyl 27.6 uM 18.8846 < 1e-12
thiabendazole 500 uM 18.7049 < 1e-12
fenbendazole 500 uM 17.8685 < 1e-12
nocodazole 2 ug/ml 17.597 < 1e-12
nocodazole 6.6 uM 17.4777 < 1e-12
thiabendazole 500 uM 17.3599 < 1e-12
fenbendazole 250 uM 15.828 < 1e-12
thiabendazole 250 uM 15.6692 < 1e-12

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for TUB3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 16.5932 < 1e-12
benomyl 10 ug/ml 16.1437 < 1e-12
nocodazole 10 ug/ml 15.7071 2.9746e-12
nocodazole 10 ug/ml 14.8371 7.7361e-12
benomyl 10 ug/ml 14.4208 1.2433e-11
benomyl 10 ug/ml 14.0703 0.00038877
latrunculin 0.78 uM 7.50225 0.0086536
ph4 7.5 6.84323 1.0504e-06
aureobasidin a 0.02 ug/ml 6.12313 4.3833e-06
rapamycin 9 nM 5.69227 0.014752

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YML124C

Top 10 functional gene interactors with YML124C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with TUB3 by heterozygous co-sensitivity:

Query Interactor Correlation
TUB3 YJL009W 0.46099
TUB3 YJL015C 0.38708
TUB3 CCT5 0.38669
TUB3 PFD1 0.37766
TUB3 YML094C-A 0.37022
TUB3 PAC10 0.36396
TUB3 GIM5 0.35283
TUB3 CCT3 0.33847
TUB3 BIM1 0.32999
TUB3 TCP1 0.32999

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
 
Homozygous co-fitness interactions

Top 10 interactors with TUB3 by homozygous co-sensitivity:

Query Interactor Correlation
TUB3 CIN1 0.4381
TUB3 MRH4 0.40651
TUB3 CIN2 0.39689
TUB3 YLR434C 0.38551
TUB3 CDH1 0.35232
TUB3 PET130 0.34783
TUB3 RPL8B 0.3456
TUB3 RPL13A 0.34336
TUB3 PFD1 0.34177
TUB3 SRP40 0.34121

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None




External information about YML124C

Other databases:

Visit YML124C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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