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YML122C / YML122C


Section 1: Phenotypes.
Gene-drug relationships for YML122C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YML122C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see The Chemical Genomic Portrait of Yeast.

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Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YML122C Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
helenine 250 uM 11.4648 < 1e-12
solasodine 250 uM 10.9072 < 1e-12
helenine 250 uM 10.6003 < 1e-12
amphotericin b 10 uM 10.2186 < 1e-12
paraquat 2000 uM 10.1738 7.4232e-12
AG 957 (Biomol) 500 uM 9.37895 5.3128e-11
clotrimazole 1 uM 8.71093 1.2932e-11
lovastatin 154.5 uM 8.41753 3.2173e-11
paraquat 5000 uM 8.04441 1.7408e-09
doxorubicin 62.5 uM 8.01705 1.2174e-10

More... (click to see all Heterozygous data)
 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YML122C Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 18.872 0.001398
rapamycin 9 nM 15.0146 0.0022032
rapamycin 9 nM 9.52169 0.0054254
synthetic complete for BY4743 0 8.83443 0.0015284
latrunculin 0.78 uM 8.77882 0.0063642
mms 0.002 % 5.65645 0.014931
curcumin 150 uM 3.13548 0.0028587
latrunculin 0.78 uM 3.13297 0.025973
latrunculin 0.78 uM 3.12098 0.002951
minimal media 0 2.74085 0.0069663

More... (click to see all Homozygous data)



Section 2: Co-fitness interactions.
Gene-gene relationships for YML122C

Top 10 functional gene interactors with YML122C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.


Heterozygous co-fitness interactions

Top 10 interactors with YML122C by heterozygous co-sensitivity:

Query Interactor Correlation
YML122C PHO84 0.75511
YML122C NFS1 0.31061
YML122C YNL235C 0.30707
YML122C CDC36 0.30549
YML122C BEM1 0.30033
YML122C MED7 0.29639
YML122C YDR290W 0.2947
YML122C URE2 0.29109
YML122C SEC14 0.29078
YML122C YOR325W 0.28803

More... (click to see all interactions)

 Enriched GO terms of interactors

Process:Function:Component:
 
Homozygous co-fitness interactions

Top 10 interactors with YML122C by homozygous co-sensitivity:

Query Interactor Correlation
YML122C SIN4 0.48456
YML122C SAM2 0.37842
YML122C YJR079W 0.37264
YML122C STP1 0.3684
YML122C YAL061W 0.36503
YML122C SUE1 0.36306
YML122C YNL011C 0.3603
YML122C YJR100C 0.35158
YML122C MED1 0.34896
YML122C SSA1 0.34776

More... (click to see all interactions)

 Enriched GO terms of interactors

Process:Function:Component:



External information about YML122C

Other databases:

Visit YML122C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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