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Yeast Fitness
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YML120C / NDI1



Section 1: Phenotypes.
Gene-drug relationships for YML120C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YML120C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for NDI1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
bithionol 75 uM 10.4993 < 1e-12
bithionol 75 uM 8.14955 7.787e-11
bithionol 75 uM 7.76062 2.9221e-10
dyclonine 500 uM 7.23173 5.2019e-06
lapachol 1000 uM 5.46078 8.7225e-07
fenpropimorph 2.3 uM 4.00996 0.00086521
dyclonine 500 uM 3.7251 0.0014499
mitomycin c 1000 uM 3.46797 0.0005662
itraconazole 37.6 uM 3.18977 0.001268
fenpropimorph 4.7 uM 3.08537 0.001701

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for NDI1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mitomycin c 1000 uM 11.3476 < 1e-12
wiskostatin 29 uM 8.35332 4.7187e-10
mechlorethamine 62.5 uM 6.7022 0.010773
nocodazole 10 ug/ml 5.79613 8.578e-06
zncl2 1875 uM 5.29262 3.5809e-06
latrunculin 0.78 uM 4.96832 0.019103
mechlorethamine 62.5 uM 4.58224 0.022236
latrunculin 3 uM 4.5079 0.00013611
licl 150 mM 3.9893 0.00016695
latrunculin 0.78 uM 3.51164 0.036198

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YML120C

Top 10 functional gene interactors with YML120C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with NDI1 by heterozygous co-sensitivity:

Query Interactor Correlation
NDI1 YJL055W 0.52521
NDI1 APS2 0.50664
NDI1 FPR3 0.48669
NDI1 YJR056C 0.48065
NDI1 TIP41 0.47618
NDI1 YLR455W 0.47128
NDI1 GRE2 0.46969
NDI1 CYC1 0.46614
NDI1 AIR1 0.45067
NDI1 TDH2 0.44642

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with NDI1 by homozygous co-sensitivity:

Query Interactor Correlation
NDI1 BSC5 0.59613
NDI1 YLR408C 0.58831
NDI1 YRF1-6 0.5718
NDI1 SNZ1 0.56664
NDI1 DAL5 0.56516
NDI1 SMA2 0.56072
NDI1 GPM3 0.55644
NDI1 SPO19 0.55556
NDI1 YKL050C 0.55434
NDI1 AQY2 0.53822

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YML120C

Other databases:

Visit YML120C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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