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YML114C / TAF8

Section 1: Phenotypes.
Gene-drug relationships for YML114C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YML114C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TAF8 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 8.93454 1.6553e-10
wiskostatin 29 uM 7.11873 2.2273e-08
bufexamac 1000 uM 4.59871 1.6101e-05
bufexamac 1000 uM 4.36682 3.4437e-05
caspofungin 10 nM 4.10525 7.9859e-05
latrunculin 1.95 uM 4.08316 0.00013855
cantharidin 250 uM 3.5939 0.034727
methotrexate 500 uM 3.10252 0.0019956
methotrexate 500 uM 2.80066 0.0042892
methotrexate 500 uM 2.78485 0.0044604

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YML114C

Top 10 functional gene interactors with YML114C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with TAF8 by heterozygous co-sensitivity:

Query Interactor Correlation
TAF8 YMR098C 0.5751
TAF8 OST5 0.55377
TAF8 GCN2 0.53111
TAF8 PFS2 0.52089
TAF8 IPL1 0.51099
TAF8 GAA1 0.50505
TAF8 YDL094C 0.50334
TAF8 NOP8 0.50229
TAF8 TRS31 0.50169
TAF8 BET3 0.50045

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YML114C

Other databases:

Visit YML114C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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