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YML105C / SEC65

Section 1: Phenotypes.
Gene-drug relationships for YML105C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YML105C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SEC65 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
thiabendazole 250 uM 6.61068 1.594e-08
bithionol 75 uM 6.10565 9.3116e-08
sodium sulfate 625 uM 5.46296 2.5823e-06
methotrexate 500 uM 5.30526 4.0873e-06
methotrexate 500 uM 5.28414 4.3465e-06
drofenine hydrochloride 750 uM 4.89286 6.0367e-06
paraquat 2000 uM 4.66367 2.6338e-05
licl 150 mM 3.61822 0.00050493
paraquat 2000 uM 3.28282 0.001245
dyclonine 500 uM 3.11548 0.0015636

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YML105C

Top 10 functional gene interactors with YML105C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with SEC65 by heterozygous co-sensitivity:

Query Interactor Correlation
SEC65 VPS69 0.58496
SEC65 PGA3 0.57333
SEC65 YRB2 0.55294
SEC65 ECM16 0.55007
SEC65 NAF1 0.53402
SEC65 MRPL51 0.52503
SEC65 CAF17 0.52488
SEC65 YML094C-A 0.52183
SEC65 MED11 0.52147
SEC65 YCR064C 0.52034

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YML105C

Other databases:

Visit YML105C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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