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YML076C / WAR1



Section 1: Phenotypes.
Gene-drug relationships for YML076C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YML076C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for WAR1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
fk506 0.1 ug/ml 4.88981 1.3683e-05
fk506 0.1 ug/ml 4.86919 1.4527e-05
nacl 600 mM 3.79415 0.00031109
methotrexate 250 uM 3.69706 0.00040675
latrunculin 6.25 uM 3.59408 0.0012147
nacl 700 mM 3.37797 0.00096676
paraquat 2000 uM 3.34177 0.0010647
perillic acid 250 uM 3.33932 0.00082543
nacl 700 mM 3.33669 0.0010792
floxuridine 80000 uM 3.33646 0.00083231

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for WAR1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
licl 150 mM 7.79839 2.2395e-09
licl 150 mM 7.44026 6.2336e-09
fk506 0.05 ug/ml 6.10895 3.1106e-07
nocodazole 10 ug/ml 5.37635 2.0708e-05
wiskostatin 29 uM 4.47082 4.1227e-05
fk506 0.1 ug/ml 4.34287 5.9984e-05
nacl 600 mM 3.69932 0.00037977
licl 100 mM 3.37059 0.0017031
nocodazole 10 ug/ml 3.09627 0.003115
nitric oxide 800 uM 3.03065 0.0027314

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YML076C

Top 10 functional gene interactors with YML076C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with WAR1 by heterozygous co-sensitivity:

Query Interactor Correlation
WAR1 MMT2 0.38833
WAR1 FCY1 0.37968
WAR1 YPR063C 0.3793
WAR1 TMA7 0.36499
WAR1 YMR144W 0.3634
WAR1 CCW14 0.35693
WAR1 YLR460C 0.35331
WAR1 YGR290W 0.34895
WAR1 MNT4 0.33389
WAR1 YPR096C 0.33367

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with WAR1 by homozygous co-sensitivity:

Query Interactor Correlation
WAR1 CDA1 0.58
WAR1 RCN1 0.54013
WAR1 HMX1 0.53573
WAR1 YOR114W 0.51779
WAR1 YJR146W 0.48978
WAR1 YER067C-A 0.47541
WAR1 SKS1 0.46638
WAR1 SSP2 0.46438
WAR1 CAR2 0.45037
WAR1 YNL303W 0.44397

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:




External information about YML076C

Other databases:

Visit YML076C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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