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YML063W / RPS1B



Section 1: Phenotypes.
Gene-drug relationships for YML063W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YML063W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPS1B Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 250 uM 5.19157 0.017579
drofenine hydrochloride 750 uM 4.33969 3.761e-05
fenpropimorph 4.7 uM 3.7769 0.00022299
propiomazine maleate 500 uM 3.32928 0.00084982
dihydromotuporamine C 15 uM 3.30928 0.0011607
pimethixene maleate 125 uM 3.24533 0.0010823
amoxepine 500 uM 3.2157 0.0011779
fenpropimorph 8 nM 3.06085 0.0018211
caspofungin 50 nM 3.03426 0.0019604
dyclonine 500 uM 3.03236 0.0019707

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPS1B Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 10.0651 4.0406e-09
rapamycin 9 nM 8.55717 0.0066915
latrunculin 0.78 uM 3.55184 0.035468
rapamycin 9 nM 2.13392 0.061278
thimerosal 125 nM 1.84177 0.041024
latrunculin 0.78 uM 1.27288 0.14637
papuamide b 0.37 ug/ml 1.25992 0.11189
latrunculin 0.78 uM 1.18176 0.12634
psoralen 0.5 uM 1.15667 0.13126
no drug irradiated 0 1.04406 0.15514

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YML063W

Top 10 functional gene interactors with YML063W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPS1B by heterozygous co-sensitivity:

Query Interactor Correlation
RPS1B RPS17A 0.69246
RPS1B BUB1 0.61309
RPS1B YPR136C 0.61053
RPS1B RPS16A 0.60801
RPS1B RPS27B 0.60382
RPS1B UTP18 0.60369
RPS1B RPS21B 0.5997
RPS1B RPS23B 0.59638
RPS1B RPS16B 0.5833
RPS1B RPS11A 0.58067

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YML063W

Other databases:

Visit YML063W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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