Retrieving results for YML060W, please wait...

Yeast Fitness
Database

Quick Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  
Advanced search

YML060W / OGG1



Section 1: Phenotypes.
Gene-drug relationships for YML060W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YML060W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for OGG1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
econazole nitrate 0.24 uM 6.43988 2.8968e-08
fluconazole 130.6 uM 5.07817 3.2276e-06
miconazole 0.2 uM 5.07711 3.2392e-06
aklavin hydrochloride 500 uM 4.78833 8.5713e-06
trichlormethine 1000 uM 4.78666 8.6193e-06
oxethazine 250 uM 4.61344 1.5336e-05
miconazole 0.2 uM 4.42231 0.0002135
miconazole 100 uM 4.38317 3.2654e-05
drofenine hydrochloride 750 uM 4.29567 4.3371e-05
latrunculin 6.25 uM 3.96965 0.00055002

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for OGG1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
sorbitol 1.5e+06 uM 7.06831 9.4349e-07
nocodazole 10 ug/ml 6.83404 1.0692e-06
mncl2 2 mM 6.39907 1.312e-07
methotrexate 250 uM 4.40065 8.1731e-05
thimerosal 125 nM 4.24685 0.00024252
ph4 7.5 4.21656 0.00025939
nocodazole 10 ug/ml 4.09315 0.00034127
ID 621889 125 uM 4.09107 0.00012461
ph4 7.5 3.78729 0.00067453
rapamycin 9 nM 3.64738 0.033816

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YML060W

Top 10 functional gene interactors with YML060W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with OGG1 by heterozygous co-sensitivity:

Query Interactor Correlation
OGG1 YML087C 0.6316
OGG1 YML089C 0.5562
OGG1 GAL80 0.54609
OGG1 CLU1 0.53525
OGG1 YML057C-A 0.53347
OGG1 YML084W 0.53316
OGG1 FLC2 0.53179
OGG1 YAR029W 0.53006
OGG1 YML030W 0.52542
OGG1 GDH3 0.52115

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with OGG1 by homozygous co-sensitivity:

Query Interactor Correlation
OGG1 MTL1 0.63167
OGG1 THO1 0.52935
OGG1 YML083C 0.52521
OGG1 TIR1 0.52482
OGG1 ISF1 0.52322
OGG1 MF(ALPHA)1 0.50985
OGG1 ATG22 0.50819
OGG1 MSS1 0.50815
OGG1 MAM1 0.50558
OGG1 RPL41B 0.50546

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YML060W

Other databases:

Visit YML060W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


Download a plain text version of this page.