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Yeast Fitness
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YML052W / SUR7



Section 1: Phenotypes.
Gene-drug relationships for YML052W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YML052W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SUR7 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
acriflavinium hydrochloride 250 uM 6.29784 4.7595e-08
drofenine hydrochloride 750 uM 5.87831 2.0556e-07
miconazole 0.2 uM 5.63481 1.8634e-05
atorvastatin 125 uM 5.43421 9.5576e-07
clozapine 125 uM 5.42007 1.0034e-06
bufexamac 1000 uM 5.28396 1.6005e-06
bufexamac 1000 uM 5.2459 1.823e-06
itraconazole 8.8 uM 5.04091 3.6622e-06
fenpropimorph 8 nM 4.88614 6.1746e-06
paroxetine hydrochloride 250 uM 4.20966 5.7213e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SUR7 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mms 0.002 % 16.3959 0.0018496
mechlorethamine 62.5 uM 6.53539 0.011311
hgcl2 62.5 uM 5.83565 7.0391e-07
cocl2 1250 uM 5.30176 3.4842e-06
mechlorethamine 62.5 uM 5.09116 0.018241
cisplatin 62.5 uM 4.79708 2.871e-05
synthetic complete for BY4743 0 3.995 0.0026115
synthetic complete for BY4743 0 3.89949 0.0029514
latrunculin 0.78 uM 3.6657 0.033512
synthetic complete for BY4743 0 3.63536 0.0041692

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YML052W

Top 10 functional gene interactors with YML052W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SUR7 by heterozygous co-sensitivity:

Query Interactor Correlation
SUR7 YML083C 0.65151
SUR7 YML053C 0.61658
SUR7 YML089C 0.61235
SUR7 FUN26 0.61185
SUR7 YAR029W 0.60973
SUR7 PRM9 0.60162
SUR7 YMR007W 0.59998
SUR7 YAR037W_d 0.59744
SUR7 YML087C 0.59626
SUR7 BDH1 0.58927

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SUR7 by homozygous co-sensitivity:

Query Interactor Correlation
SUR7 PLB1 0.77063
SUR7 PRM9 0.74825
SUR7 PLB2 0.72865
SUR7 ATG2 0.71167
SUR7 YIL059C 0.70776
SUR7 MST27 0.69487
SUR7 SNZ2 0.68771
SUR7 STE13 0.67443
SUR7 YGR235C 0.65309
SUR7 YDL129W 0.64632

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YML052W

Other databases:

Visit YML052W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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