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Yeast Fitness
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YML008C / ERG6



Section 1: Phenotypes.
Gene-drug relationships for YML008C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YML008C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ERG6 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
solasodine 250 uM 9.25058 3.4842e-12
itraconazole 17.7 uM 6.79155 8.4686e-09
latrunculin 6.25 uM 4.59982 0.00014794
methotrexate 500 uM 3.40116 0.0009086
atorvastatin 125 uM 3.34594 0.00080971
clozapine 500 uM 3.20365 0.001219
caspofungin 50 nM 3.18639 0.0012803
drofenine hydrochloride 750 uM 3.13484 0.0014809
5-fluorouracil 38.5 uM 3.01215 0.014841
clofoctol 1000 uM 2.87311 0.0030415

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ERG6 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
sorbitol 1.5e+06 uM 4.5834 0.00013212
bleomycin 1.13 ug/ml 3.92835 0.00049259
synthetic complete for BY4743 0 3.92792 0.00054201
minimal media 0 3.92078 0.00055046
lysine dropout 0 3.4699 0.0014645
latrunculin 0.78 uM 3.36883 0.0017098
bleomycin 1.7 ug/ml 3.35692 0.0017554
sorbitol 1.5e+06 uM 3.04152 0.0036858
nocodazole 10 ug/ml 3.01257 0.0037391
latrunculin 0.78 uM 2.98832 0.0039416

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YML008C

Top 10 functional gene interactors with YML008C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ERG6 by heterozygous co-sensitivity:

Query Interactor Correlation
ERG6 SPT5 0.78234
ERG6 TAF4 0.75419
ERG6 EFB1 0.75383
ERG6 YML009W-B 0.75379
ERG6 SEL1 0.74677
ERG6 YML6 0.74456
ERG6 TRM9 0.74043
ERG6 MDM10 0.73604
ERG6 SEC59 0.73603
ERG6 DEM1 0.73045

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ERG6 by homozygous co-sensitivity:

Query Interactor Correlation
ERG6 PHO88 0.70574
ERG6 SLX8 0.66534
ERG6 LEA1 0.64794
ERG6 SAC1 0.63763
ERG6 VRP1 0.63493
ERG6 MSK1 0.63194
ERG6 GLE2 0.62713
ERG6 NGG1 0.62368
ERG6 MSL1 0.59803
ERG6 YJR018W 0.59729

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YML008C

Other databases:

Visit YML008C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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