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Yeast Fitness
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YML004C / GLO1



Section 1: Phenotypes.
Gene-drug relationships for YML004C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YML004C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GLO1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
clozapine 500 uM 5.39685 1.0868e-06
itraconazole 17.7 uM 5.11023 2.8947e-06
pyrithione zinc 1.95 uM 4.90002 5.893e-06
hygromycin 0.4 uM 4.75433 9.6024e-06
latrunculin 6.25 uM 4.65981 0.00013077
drofenine hydrochloride 750 uM 4.31033 4.1363e-05
itraconazole 35.4 uM 4.19898 5.9206e-05
nicardipine hydrochloride 500 uM 4.18967 6.0998e-05
trichostatin A 3.91 uM 4.15218 0.00011398
caspofungin 50 nM 3.91246 0.00014656

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for GLO1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
rapamycin 9 nM 5.57322 0.01536
mitomycin c 1000 uM 4.89465 1.1758e-05
5-fluorouracil 38.5 uM 4.63899 4.3585e-05
mechlorethamine 62.5 uM 4.27671 0.00011325
mechlorethamine 62.5 uM 3.9207 0.029662
myriocin 0.2 ug/ml 3.80765 0.00064462
streptovitacin 31.25 uM 3.70667 0.00037203
thimerosal 125 nM 3.70176 0.00081613
rapamycin 9 nM 3.27296 0.041014
nocodazole 10 ug/ml 3.20599 0.0024488

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YML004C

Top 10 functional gene interactors with YML004C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with GLO1 by heterozygous co-sensitivity:

Query Interactor Correlation
GLO1 YMR018W 0.66235
GLO1 YML003W 0.6457
GLO1 CLU1 0.62463
GLO1 ADI1 0.59709
GLO1 YML030W 0.58555
GLO1 SPO20 0.56747
GLO1 IMP2 0.56357
GLO1 TRM12 0.55472
GLO1 HXT2 0.55375
GLO1 YMR007W 0.54864

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with GLO1 by homozygous co-sensitivity:

Query Interactor Correlation
GLO1 COS1 0.61583
GLO1 TWF1 0.5704
GLO1 YML020W 0.56153
GLO1 YJL068C 0.54634
GLO1 YNL086W 0.53416
GLO1 FKH1 0.52208
GLO1 SNC1 0.52007
GLO1 HSP104 0.51461
GLO1 FMP12 0.51353
GLO1 YNL195C 0.51218

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YML004C

Other databases:

Visit YML004C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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