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YML001W / YPT7



Section 1: Phenotypes.
Gene-drug relationships for YML001W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YML001W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YPT7 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
hygromycin 0.4 uM 6.88996 6.0039e-09
itraconazole 17.7 uM 6.60291 1.6379e-08
dyclonine 500 uM 4.30512 0.0005113
ketoconazole 11.8 uM 4.22153 0.00032432
paromomycin sulfate 500 uM 3.11609 0.0015609
5-fluorouridine 95 uM 2.91613 0.0027084
tunicamycin 0.15 uM 2.85424 0.017823
benzyl benzoate 1000 uM 2.83469 0.0033708
dimercaptopropanol 500 uM 2.59788 0.0062435
colchiceine 250 uM 2.50574 0.0078703

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YPT7 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
licl 100 mM 32.9903 < 1e-12
papuamide b 0.7 ug/ml 31.7391 < 1e-12
synthetic complete for BY4743 0 26.7639 6.1233e-11
synthetic complete for BY4743 0 26.493 6.7701e-11
tryptophan dropout 0 25.8781 8.5356e-11
rapamycin 9 nM 24.3131 0.0008437
bleomycin 1.13 ug/ml 23.3738 < 1e-12
bleomycin 1.13 ug/ml 23.3157 < 1e-12
bleomycin 1.7 ug/ml 22.4972 < 1e-12
bleomycin 1.7 ug/ml 20.52 < 1e-12

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YML001W

Top 10 functional gene interactors with YML001W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YPT7 by heterozygous co-sensitivity:

Query Interactor Correlation
YPT7 ADE1 0.86316
YPT7 ATS1 0.81791
YPT7 YML6 0.79043
YPT7 OST6 0.78375
YPT7 SEL1 0.75504
YPT7 SPT5 0.74336
YPT7 PSP2 0.74106
YPT7 CCS1 0.71787
YPT7 TRM9 0.71626
YPT7 YIL067C 0.71374

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YPT7 by homozygous co-sensitivity:

Query Interactor Correlation
YPT7 CCZ1 0.80786
YPT7 APL6 0.73291
YPT7 APS3 0.72331
YPT7 VAM7 0.7233
YPT7 VAM6 0.70971
YPT7 MON1 0.69621
YPT7 APM3 0.66962
YPT7 VPS41 0.63918
YPT7 APL5 0.5653
YPT7 FLC2 0.47906

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YML001W

Other databases:

Visit YML001W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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