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YLR458W / YLR458W



Section 1: Phenotypes.
Gene-drug relationships for YLR458W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR458W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YLR458W Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
fluconazole 130.6 uM 8.69767 1.3449e-11
dmso 4% 4 uM 6.68036 1.2493e-08
drofenine hydrochloride 750 uM 6.53329 2.0894e-08
5-fluorocytosine 15.6 uM 5.21399 2.0329e-06
thiabendazole 500 uM 4.68412 1.2132e-05
itraconazole 35.4 uM 4.57566 1.7375e-05
fluconazole 65.3 uM 4.02917 0.00010162
5-fluorocytosine 15.6 uM 3.99415 0.00011347
fluconazole 65.3 uM 3.72985 0.00025758
wiskostatin 29 uM 3.56244 0.00058787

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YLR458W

Top 10 functional gene interactors with YLR458W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YLR458W by heterozygous co-sensitivity:

Query Interactor Correlation
YLR458W RIB4 0.66452
YLR458W YMR293C 0.66207
YLR458W MTG1 0.65863
YLR458W PEP5 0.657
YLR458W PRP16 0.65494
YLR458W RRN9 0.63296
YLR458W BET4 0.62742
YLR458W ATP12 0.62618
YLR458W RNA1 0.62494
YLR458W YJL032W 0.62275

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YLR458W

Other databases:

Visit YLR458W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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