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Yeast Fitness
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YLR403W / SFP1



Section 1: Phenotypes.
Gene-drug relationships for YLR403W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR403W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SFP1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 13.2564 2.1829e-05
no drug minimal media 0 12.0427 3.4841e-05
no drug minimal media 0 8.88633 0.00015013
no drug minimal media 0 3.70634 0.0069538
doxorubicin 62.5 uM 3.32392 0.00086313
no drug minimal media 0 3.06032 0.014046
methoxsalen 500 uM 3.05005 0.0018765
no drug minimal media 0 2.80677 0.018846
5-fluorouracil 38.5 uM 2.75348 0.0070664
sulfanilamide 62.5 uM 2.51058 0.0077761

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SFP1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 10.6048 1.7956e-09
synthetic complete for BY4743 0 4.20701 0.0042162
rapamycin 9 nM 3.86452 0.030453
papuamide b 0.7 ug/ml 2.8859 0.0049202
dmaec 240000 uM 2.32842 0.015872
synthetic complete for BY4743 0 1.89301 0.050116
no drug irradiated 0 1.81401 0.043191
mechlorethamine 62.5 uM 1.46799 0.13991
psoralen 0.5 uM 1.36336 0.09479
benomyl 10 ug/ml 1.35091 0.096731

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLR403W

Top 10 functional gene interactors with YLR403W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SFP1 by heterozygous co-sensitivity:

Query Interactor Correlation
SFP1 YMR098C 0.57889
SFP1 HUT1 0.5753
SFP1 AUR1 0.56325
SFP1 YNL187W 0.5585
SFP1 IPL1 0.54686
SFP1 GCN2 0.54609
SFP1 YOR292C 0.54518
SFP1 RPN7 0.54426
SFP1 HSF1 0.54177
SFP1 FUM1 0.539

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YLR403W

Other databases:

Visit YLR403W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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