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Yeast Fitness
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YLR399C / BDF1



Section 1: Phenotypes.
Gene-drug relationships for YLR399C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR399C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for BDF1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 11.4274 < 1e-12
methotrexate 500 uM 11.2658 < 1e-12
fk506 0.05 ug/ml 8.01965 1.8612e-09
metergoline 250 uM 5.8423 2.3298e-07
nacl 600 mM 5.74415 1.1397e-06
methotrexate 125 uM 5.69581 1.3116e-06
cantharidin 250 uM 5.05623 8.4374e-06
methotrexate 500 uM 4.98604 1.0347e-05
methotrexate 500 uM 4.70233 2.3554e-05
cantharidin 250 uM 4.5886 0.022179

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for BDF1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 2.45329 0.028851
synthetic complete for BY4743 0 1.85924 0.061045

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLR399C

Top 10 functional gene interactors with YLR399C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with BDF1 by heterozygous co-sensitivity:

Query Interactor Correlation
BDF1 YFR042W 0.64913
BDF1 YGR251W 0.64611
BDF1 BET2 0.63208
BDF1 URB1 0.62848
BDF1 PRS1 0.62309
BDF1 PRP40 0.6207
BDF1 TOR2 0.61639
BDF1 SRP21 0.61283
BDF1 MMS1 0.61237
BDF1 UTP20 0.60116

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YLR399C

Other databases:

Visit YLR399C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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