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Yeast Fitness
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YLR398C / SKI2



Section 1: Phenotypes.
Gene-drug relationships for YLR398C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR398C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SKI2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cuso4 10000 uM 3.93957 0.00020746
cantharidin 250 uM 3.79891 0.031416
dihydromotuporamine C 7.5 uM 3.38456 0.00094986
thimerosal 125 nM 3.33866 0.0010736
no drug minimal media 0 3.03069 0.014529
403818 125 uM 2.97635 0.0027587
menadione epoxide 62.5 uM 2.97448 0.0027719
nsc95397 125 uM 2.68088 0.0057552
methotrexate 250 uM 2.61428 0.0067596
l-dopa 12.5 ug/ml 2.53977 0.0080743

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SKI2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 7.21174 1.4429e-05
potassium disulfite 2500 uM 6.78259 1.1814e-06
synthetic complete for BY4743 0 5.70751 9.8135e-05
cycloheximide 32.3 uM 5.16318 5.2751e-06
hydroxyurea 50000 uM 4.98913 8.872e-06
hydroxyurea 100000 uM 4.91741 1.0987e-05
streptovitacin 31.25 uM 3.99251 0.00016542
methotrexate 250 uM 3.72194 0.00048065
synthetic complete for BY4743 400 uM 3.71139 0.0008672
hygromycin 13.75 uM 3.49405 0.00067136

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLR398C

Top 10 functional gene interactors with YLR398C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SKI2 by heterozygous co-sensitivity:

Query Interactor Correlation
SKI2 YDL009C 0.51056
SKI2 SCM4 0.49041
SKI2 YRB30 0.48413
SKI2 MGA1 0.4771
SKI2 BSP1 0.4547
SKI2 COY1 0.44807
SKI2 FRE2 0.4327
SKI2 SMK1 0.42853
SKI2 YFR056C 0.42722
SKI2 DCW1 0.42592

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SKI2 by homozygous co-sensitivity:

Query Interactor Correlation
SKI2 SKI8 0.71169
SKI2 SKI3 0.69575
SKI2 YGL214W 0.59888
SKI2 SLH1 0.54448
SKI2 MTH1 0.5095
SKI2 HMF1 0.50903
SKI2 YOR251C 0.50447
SKI2 YJR056C 0.50143
SKI2 SKI7 0.4818
SKI2 UBA4 0.47973

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None




External information about YLR398C

Other databases:

Visit YLR398C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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