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Yeast Fitness
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YLR395C / COX8



Section 1: Phenotypes.
Gene-drug relationships for YLR395C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR395C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for COX8 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
tryptanthrin 250 uM 3.42843 0.00084452
aminopterin 125 uM 2.92345 0.0031546
methotrexate 500 uM 2.87577 0.0035568
dyclonine 500 uM 2.70414 0.009581
haloperidol 250 uM 2.66247 0.010348
dyclonine 500 uM 2.53303 0.013136
dihydromotuporamine C 7.5 uM 2.3166 0.013542
dmso 4% 4 uM 2.22543 0.015444
myriocin 0.15 ug/ml 2.205 0.01738
pp2 100 uM 2.02912 0.025416

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for COX8 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mitomycin c 1000 uM 21.6289 < 1e-12
wiskostatin 29 uM 4.96075 9.6557e-06
aureobasidin a 0.02 ug/ml 4.2007 0.00026869
potassium disulfite 2500 uM 4.04284 0.00038171
myriocin 0.2 ug/ml 3.52849 0.0012
zncl2 1875 uM 3.47001 0.00071714
synthetic complete for BY4743 0 3.42777 0.020803
rapamycin 6 nM 3.42065 0.00082076
mitomycin c 1000 uM 3.22751 0.0023356
synthetic complete for BY4743 0 3.17917 0.043161

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLR395C

Top 10 functional gene interactors with YLR395C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with COX8 by heterozygous co-sensitivity:

Query Interactor Correlation
COX8 YBR137W 0.69785
COX8 RCK1 0.6855
COX8 YCL002C 0.68008
COX8 YGR058W 0.66229
COX8 REH1 0.6558
COX8 SPE1 0.64627
COX8 YJL007C 0.6445
COX8 RPS27A 0.63968
COX8 NIT3 0.63479
COX8 TPC1 0.63396

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with COX8 by homozygous co-sensitivity:

Query Interactor Correlation
COX8 YER130C 0.63809
COX8 SAK1 0.60613
COX8 YEL008W 0.56533
COX8 ARO10 0.55739
COX8 ADY2 0.52568
COX8 YDR445C 0.51385
COX8 COX17 0.49147
COX8 COX9 0.48434
COX8 TDP1 0.48049
COX8 YCL033C 0.46688

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YLR395C

Other databases:

Visit YLR395C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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