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YLR392C / YLR392C



Section 1: Phenotypes.
Gene-drug relationships for YLR392C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR392C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YLR392C Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 5.63679 1.5571e-06
dmso 4% 4 uM 5.0353 3.7325e-06
latrunculin 1.95 uM 4.96706 1.0934e-05
tryptanthrin 250 uM 4.36698 6.1821e-05
methotrexate 250 uM 3.26396 0.0013086
methotrexate 125 uM 3.19857 0.0015541
5-fluorocytosine 15.6 uM 2.80911 0.003608
alverine citrate 500 uM 2.71491 0.056556
AG 957 (Biomol) 500 uM 2.68752 0.005663
no drug minimal media 0 2.67062 0.022158

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YLR392C Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
fk506 200 uM 5.4329 2.3523e-06
fk506 50 uM 5.12908 5.8412e-06
fk506 100 uM 5.01298 8.2625e-06
latrunculin 0.78 uM 4.10998 0.013041
cadmium chloride 7.81 uM 4.07522 0.00013044
thiabendazole 250 uM 4.04858 0.00020591
mitomycin c 1000 uM 3.6516 0.00043397
latrunculin 0.78 uM 3.50744 0.036276
latrunculin 0.78 uM 3.20607 0.0024484
wiskostatin 29 uM 3.04249 0.0022504

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLR392C

Top 10 functional gene interactors with YLR392C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YLR392C by heterozygous co-sensitivity:

Query Interactor Correlation
YLR392C YNK1 0.47028
YLR392C YLR408C 0.44546
YLR392C SUB1 0.44451
YLR392C YIL092W 0.44247
YLR392C CPR2 0.43829
YLR392C PLB1 0.43743
YLR392C YKL047W 0.43634
YLR392C ISN1 0.43518
YLR392C RPS22B 0.43383
YLR392C FAA3 0.43382

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YLR392C by homozygous co-sensitivity:

Query Interactor Correlation
YLR392C YOR114W 0.68822
YLR392C YNL303W 0.62536
YLR392C RPS9A 0.62251
YLR392C MTQ1 0.61613
YLR392C IRC2 0.59726
YLR392C GLO4 0.59514
YLR392C YBR116C 0.59014
YLR392C YLR271W 0.58947
YLR392C YGR042W 0.58631
YLR392C YCR100C 0.57842

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YLR392C

Other databases:

Visit YLR392C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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