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Yeast Fitness
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YLR354C / TAL1



Section 1: Phenotypes.
Gene-drug relationships for YLR354C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR354C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TAL1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 4.27266 0.0026238
no drug minimal media 0 4.20056 0.0042425
no drug minimal media 0 4.08198 0.0047607
bay 11-7082 12.5 uM 3.46239 0.00077077
thiabendazole 250 uM 2.48701 0.0091435
4-isopropyltropolone 15.63 uM 2.45006 0.0099678
cyclamin 62.5 uM 2.28701 0.014477
mit 50 uM 2.22175 0.016748
phloretin 500 uM 2.19357 0.017823
tryptanthrin 250 uM 2.18667 0.018096

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for TAL1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
paraquat 5000 uM 11.6236 < 1e-12
paraquat 5000 uM 8.38575 4.3131e-10
wiskostatin 29 uM 7.91066 1.6294e-09
synthetic complete for BY4743 0 5.83839 0.014053
methotrexate 250 uM 5.12676 1.2029e-05
allyl disulfide 0.06 % 4.73904 1.8671e-05
synthetic complete for BY4743 0 4.39129 0.0035397
synthetic complete for BY4743 0 4.32371 0.00075217
zncl2 1875 uM 4.10642 0.00011922
tryptophan dropout 0 3.55735 0.0026021

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLR354C

Top 10 functional gene interactors with YLR354C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with TAL1 by heterozygous co-sensitivity:

Query Interactor Correlation
TAL1 QRI8 0.57569
TAL1 YLR235C 0.57455
TAL1 YMR041C 0.57158
TAL1 RSE1 0.56828
TAL1 CDC42 0.55918
TAL1 NMT1 0.55715
TAL1 DEP1 0.54155
TAL1 GPB2 0.53847
TAL1 SRC1 0.53735
TAL1 YBL048W 0.53393

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with TAL1 by homozygous co-sensitivity:

Query Interactor Correlation
TAL1 POL4 0.55252
TAL1 STE23 0.50836
TAL1 YLR073C 0.50462
TAL1 YGL138C 0.4923
TAL1 SAE3 0.48667
TAL1 HOT13 0.47804
TAL1 YJR030C 0.45834
TAL1 YBL044W 0.45639
TAL1 VPS15 0.45603
TAL1 UBP15 0.45339

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None




External information about YLR354C

Other databases:

Visit YLR354C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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