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Yeast Fitness
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YLR338W / OPI9



Section 1: Phenotypes.
Gene-drug relationships for YLR338W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR338W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for OPI9 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
alverine citrate 500 uM 13.924 0.0025592
methotrexate 500 uM 12.8567 < 1e-12
methotrexate 500 uM 8.49993 5.1562e-10
methotrexate 500 uM 8.27716 9.3184e-10
alverine citrate 500 uM 7.86134 0.0078993
itraconazole 17.7 uM 6.43582 2.9382e-08
cantharidin 250 uM 5.03037 0.01866
5-fluorouracil 19.2 uM 5.00245 9.8653e-06
cantharidin 250 uM 4.65097 0.021626
methotrexate 125 uM 4.53412 3.8267e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for OPI9 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
bleomycin 1.7 ug/ml 4.25237 0.00023957
bleomycin 1.13 ug/ml 3.93636 0.00048387
synthetic complete for BY4743 0 3.88953 0.0029895
bleomycin 1.7 ug/ml 3.83639 0.00060462
potassium disulfite 2500 uM 3.6053 0.0010116
papuamide b 0.7 ug/ml 3.54601 0.0011541
bleomycin 1.13 ug/ml 3.4642 0.0013841
rapamycin 9 nM 3.00058 0.0038379
licl 100 mM 2.91183 0.0046522
oxaliplatin 4000 uM 2.88653 0.0049135

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLR338W

Top 10 functional gene interactors with YLR338W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with OPI9 by heterozygous co-sensitivity:

Query Interactor Correlation
OPI9 RIO2 0.59446
OPI9 SSY1 0.52646
OPI9 POL2 0.52374
OPI9 PRP40 0.52314
OPI9 KAR3 0.52308
OPI9 TSR1 0.52094
OPI9 BET2 0.51449
OPI9 PRS1 0.51324
OPI9 SUR4 0.51187
OPI9 ALF1 0.51132

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YLR338W

Other databases:

Visit YLR338W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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