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Yeast Fitness

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YLR322W / VPS65

Section 1: Phenotypes.
Gene-drug relationships for YLR322W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR322W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for VPS65 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 6.29992 5.2861e-06
caspofungin 10 nM 6.29762 4.7632e-08
caspofungin 10 nM 5.87928 2.0488e-07
itraconazole 8.8 uM 5.85861 2.2014e-07
caspofungin 10 nM 5.85067 2.263e-07
itraconazole 4.4 uM 5.70362 3.7698e-07
itraconazole 8.8 uM 5.69873 3.8342e-07
doxorubicin 62.5 uM 5.61146 5.1864e-07
aphidicolin glycinate 125 uM 5.58431 1.8139e-06
telomerase inhibitor ix (Biomol) 500 uM 5.53215 2.1113e-06

More... (click to see all Heterozygous data)

Homozygous knockout:

Top 10 sensitivity-inducing conditions for VPS65 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 23.7959 0.00088068
mechlorethamine 62.5 uM 22.5329 0.00098187
mechlorethamine 62.5 uM 18.4199 0.0014672
potassium disulfite 2500 uM 14.3888 1.2901e-11
latrunculin 0.78 uM 12.6022 1.1427e-10
latrunculin 0.78 uM 11.9643 2.6473e-10
licl 100 mM 7.71065 2.0624e-07
latrunculin 3 uM 5.92508 6.5718e-06
synthetic complete for BY4743 0 5.55821 0.00042626
papuamide b 0.7 ug/ml 5.55622 1.4158e-05

More... (click to see all Homozygous data)

Section 2: Co-fitness interactions.
Gene-gene relationships for YLR322W

Top 10 functional gene interactors with YLR322W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with VPS65 by heterozygous co-sensitivity:

Query Interactor Correlation
VPS65 RSC58 0.53147
VPS65 RSC9 0.52432
VPS65 ATP14 0.50706
VPS65 RSC8 0.50352
VPS65 ARP9 0.47545
VPS65 MIG2 0.45887
VPS65 NPL6 0.45299
VPS65 CDA2 0.44932
VPS65 BUD20 0.43088
VPS65 SFH1 0.42835

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YLR322W

Other databases:

Visit YLR322W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
    • None
    • None
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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