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Yeast Fitness
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YLR287C-A / RPS30A



Section 1: Phenotypes.
Gene-drug relationships for YLR287C-A
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR287C-A deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPS30A Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 11.6075 < 1e-12
caspofungin 10 nM 11.0352 < 1e-12
metergoline 250 uM 10.9511 < 1e-12
drofenine hydrochloride 750 uM 9.34822 2.9706e-12
methotrexate 500 uM 9.15238 9.4524e-11
clozapine 500 uM 8.58402 1.8987e-11
wiskostatin 29 uM 8.23133 1.0533e-09
methotrexate 250 uM 7.60988 4.9111e-10
methotrexate 250 uM 7.42724 9.2404e-10
methotrexate 500 uM 7.01733 3.8484e-09

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPS30A Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
rapamycin 9 nM 22.5759 0.00097815
rapamycin 9 nM 18.2925 0.00017823
rapamycin 9 nM 15.4317 0.0020865
potassium disulfite 2500 uM 7.86022 1.5736e-07
synthetic complete for BY4743 0 3.98017 0.014187
latrunculin 0.78 uM 3.01038 0.028597
norcantharidin 2500 uM 3.00759 0.0024638
hydroxyurea 25000 uM 2.70799 0.0052588
chemdiv 41 500 uM 2.64933 0.0060736
chlorambucil 250 uM 2.54795 0.0077625

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLR287C-A

Top 10 functional gene interactors with YLR287C-A. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPS30A by heterozygous co-sensitivity:

Query Interactor Correlation
RPS30A MRPL15 0.5595
RPS30A ECM38 0.54528
RPS30A ECI1 0.54482
RPS30A BUD20 0.53098
RPS30A YLR294C 0.5236
RPS30A YIL064W 0.51983
RPS30A MEC3 0.51574
RPS30A YIL077C 0.50653
RPS30A YLR290C 0.49893
RPS30A YLR296W 0.4831

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with RPS30A by homozygous co-sensitivity:

Query Interactor Correlation
RPS30A RPS17B 0.67158
RPS30A YDL063C 0.66035
RPS30A FYV12 0.64639
RPS30A RPS29A 0.61095
RPS30A RPS10B 0.60191
RPS30A RPS0A 0.60171
RPS30A RPS28A 0.60084
RPS30A RPS18B 0.59324
RPS30A YDL062W 0.58862
RPS30A IRC13 0.58816

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YLR287C-A

Other databases:

Visit YLR287C-A in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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