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Yeast Fitness
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YLR263W / RED1



Section 1: Phenotypes.
Gene-drug relationships for YLR263W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR263W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RED1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 19.1078 < 1e-12
cantharidin 250 uM 7.94598 0.0077358
cantharidin 250 uM 7.8361 0.0079491
cantharidin 250 uM 7.38931 0.0089131
cantharidin 250 uM 7.36807 0.0089632
cantharidin 250 uM 7.27304 0.0091925
cantharidin 250 uM 7.13593 0.0095389
methotrexate 250 uM 6.65946 8.1604e-08
amphotericin b 0.31 uM 6.63499 1.4641e-08
methotrexate 125 uM 5.2594 4.6712e-06

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RED1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nocodazole 10 ug/ml 17.0626 < 1e-12
wiskostatin 29 uM 4.53472 3.416e-05
licl 100 mM 3.28713 0.002048
cadmium chloride 7.81 uM 2.80236 0.0041579
rapamycin 9 nM 2.66236 0.038093
synthetic complete for BY4743 0 2.55213 0.014379
mechlorethamine 62.5 uM 2.41789 0.047174
latrunculin 0.78 uM 2.26823 0.075713
mechlorethamine 62.5 uM 2.1189 0.084121
threonine dropout 0 2.08638 0.02616

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLR263W

Top 10 functional gene interactors with YLR263W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RED1 by heterozygous co-sensitivity:

Query Interactor Correlation
RED1 UBC5 0.43225
RED1 RAD2 0.42829
RED1 BOP2 0.39985
RED1 IRC2 0.39774
RED1 DOS2 0.39257
RED1 LTP1 0.39173
RED1 CCC1 0.38386
RED1 YDL027C 0.38273
RED1 MET17 0.3818
RED1 YLR252W 0.37439

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with RED1 by homozygous co-sensitivity:

Query Interactor Correlation
RED1 YKL151C 0.79226
RED1 MRK1 0.69279
RED1 TMA10 0.68469
RED1 FMP43 0.68418
RED1 FIN1 0.65999
RED1 YFR017C 0.65478
RED1 YAL045C 0.65274
RED1 MAL12 0.65262
RED1 ADE16 0.64985
RED1 YLR280C 0.64629

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YLR263W

Other databases:

Visit YLR263W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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