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Yeast Fitness
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YLR260W / LCB5



Section 1: Phenotypes.
Gene-drug relationships for YLR260W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR260W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for LCB5 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
fenpropimorph 4.7 uM 9.30416 3.1818e-12
latrunculin 6.25 uM 7.3776 7.8006e-07
itraconazole 4.4 uM 7.07417 3.1562e-09
itraconazole 17.7 uM 5.25711 1.7544e-06
fluconazole 31.25 uM 5.01813 3.9559e-06
haloperidol 250 uM 4.67135 0.00027012
miconazole 100 uM 4.35621 3.5645e-05
tryptanthrin 250 uM 4.2473 8.6994e-05
lapachol 1000 uM 4.12989 7.3835e-05
fluconazole 65.3 uM 4.0994 8.1357e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for LCB5 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 25.6007 < 1e-12
rapamycin 9 nM 22.8753 0.00095278
latrunculin 0.78 uM 9.60386 0.0053344
synthetic complete for BY4743 0 9.4939 0.0054566
licl 100 mM 5.4417 1.8029e-05
rapamycin 9 nM 4.29685 0.025063
latrunculin 0.78 uM 2.48513 0.044433
latrunculin 0.78 uM 2.39264 0.069567
rapamycin 9 nM 2.34806 0.050241
aureobasidin a 0.02 ug/ml 2.1734 0.021671

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLR260W

Top 10 functional gene interactors with YLR260W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with LCB5 by heterozygous co-sensitivity:

Query Interactor Correlation
LCB5 QRI5 0.53566
LCB5 SLU7 0.51546
LCB5 YLL037W 0.5131
LCB5 TAD3 0.48147
LCB5 PRP2 0.48128
LCB5 RRP1 0.48097
LCB5 APC4 0.47718
LCB5 LUC7 0.46616
LCB5 HSH49 0.44895
LCB5 ZPR1 0.44672

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YLR260W

Other databases:

Visit YLR260W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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