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Yeast Fitness
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YLR249W / YEF3



Section 1: Phenotypes.
Gene-drug relationships for YLR249W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR249W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YEF3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 9.75702 2.0621e-11
methotrexate 500 uM 8.66982 3.2974e-10
latrunculin 3.91 uM 7.09776 2.3624e-08
doxorubicin 62.5 uM 6.7057 1.1433e-08
helenine 250 uM 6.6299 1.4904e-08
helenine 250 uM 6.23258 5.9784e-08
cantharidin 250 uM 5.61282 0.015153
dyclonine 500 uM 4.30043 0.00051556
fenpropimorph 4.7 uM 4.13499 7.2644e-05
amphotericin b 0.31 uM 4.11333 7.7833e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YLR249W

Top 10 functional gene interactors with YLR249W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YEF3 by heterozygous co-sensitivity:

Query Interactor Correlation
YEF3 MTQ2 0.48169
YEF3 SPC110 0.4421
YEF3 FHL1 0.43797
YEF3 MMS22 0.40594
YEF3 YIP1 0.40589
YEF3 SWI6 0.40335
YEF3 ATP22 0.40316
YEF3 GPI16 0.39711
YEF3 SEC10 0.39573
YEF3 AME1 0.39037

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YLR249W

Other databases:

Visit YLR249W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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