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YLR208W / SEC13



Section 1: Phenotypes.
Gene-drug relationships for YLR208W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR208W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SEC13 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
alverine citrate 500 uM 26.7446 0.00069757
myriocin 0.15 ug/ml 24.9068 < 1e-12
alverine citrate 500 uM 22.0364 0.0010265
caspofungin 10 nM 14.8869 < 1e-12
caspofungin 10 nM 14.8221 < 1e-12
caspofungin 10 nM 13.7627 < 1e-12
miconazole 100 uM 12.3076 < 1e-12
miconazole 100 uM 12.1194 < 1e-12
fenpropimorph 4.7 uM 12.0428 < 1e-12
itraconazole 37.6 uM 9.19735 3.8436e-12

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YLR208W

Top 10 functional gene interactors with YLR208W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SEC13 by heterozygous co-sensitivity:

Query Interactor Correlation
SEC13 YDL041W 0.5217
SEC13 PHO2 0.41204
SEC13 YDR049W 0.41191
SEC13 HTS1 0.41134
SEC13 YDR114C 0.41037
SEC13 IRA1 0.40088
SEC13 PRE2 0.3965
SEC13 PRE3 0.3844
SEC13 SEC31 0.38368
SEC13 UTR1 0.3823

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YLR208W

Other databases:

Visit YLR208W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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