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Yeast Fitness
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YLR191W / PEX13



Section 1: Phenotypes.
Gene-drug relationships for YLR191W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR191W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PEX13 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 6.30724 2.2365e-07
dmso 4% 4 uM 6.25928 5.446e-08
fluconazole 31.25 uM 6.10562 9.3126e-08
itraconazole 8.8 uM 5.77676 2.9253e-07
methotrexate 250 uM 5.28071 4.39e-06
fluconazole 31.25 uM 5.22346 1.9682e-06
latrunculin 3.91 uM 4.92873 1.2222e-05
norcantharidin 2500 uM 4.65176 2.726e-05
itraconazole 8.8 uM 4.50548 2.1891e-05
fenbendazole 500 uM 4.07741 8.7238e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for PEX13 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mms 0.002 % 28.1443 0.00063004
allyl disulfide 0.06 % 12.005 < 1e-12
phosphatase inhibitor 3 uM 11.1925 < 1e-12
nocodazole 10 ug/ml 11.1843 7.7692e-10
phosphatase inhibitor 2 uM 11.0179 < 1e-12
mechlorethamine 62.5 uM 8.40761 0.0069267
fk506 100 uM 7.96603 1.3937e-09
mms 0.002 % 7.77543 2.3903e-09
fk506 200 uM 7.23642 1.1231e-08
wiskostatin 29 uM 6.88893 3.0928e-08

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLR191W

Top 10 functional gene interactors with YLR191W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with PEX13 by heterozygous co-sensitivity:

Query Interactor Correlation
PEX13 YPL247C 0.50068
PEX13 HPR1 0.41592
PEX13 ABZ1 0.3982
PEX13 YLR199C 0.39136
PEX13 YHR202W 0.3799
PEX13 CYM1 0.37329
PEX13 NTC20 0.37165
PEX13 SNM1 0.37062
PEX13 YMD8 0.36998
PEX13 YDR514C 0.36428

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with PEX13 by homozygous co-sensitivity:

Query Interactor Correlation
PEX13 YGL152C 0.72893
PEX13 PEX19 0.71559
PEX13 PEX3 0.71396
PEX13 PEX14 0.70569
PEX13 PEX10 0.69388
PEX13 PEX4 0.69376
PEX13 PEX17 0.68773
PEX13 PEX5 0.67071
PEX13 YJL211C 0.66905
PEX13 PEX22 0.66773

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YLR191W

Other databases:

Visit YLR191W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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