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YLR145W / RMP1



Section 1: Phenotypes.
Gene-drug relationships for YLR145W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR145W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RMP1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
itraconazole 17.7 uM 6.52505 2.1506e-08
dna protein kinase inhibitor 0 6.14375 3.582e-07
licl 150 mM 5.57241 1.8778e-06
itraconazole 4.4 uM 5.27086 1.6739e-06
thiram 15.6 uM 5.25344 1.7766e-06
5-fluorouracil 38.5 uM 5.0571 5.8327e-05
caspofungin 10 nM 4.90515 5.7922e-06
5-fluorocytosine 15.6 uM 4.13847 7.1844e-05
methotrexate 250 uM 3.60083 0.00038094
methotrexate 500 uM 3.48821 0.00071891

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YLR145W

Top 10 functional gene interactors with YLR145W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RMP1 by heterozygous co-sensitivity:

Query Interactor Correlation
RMP1 ATP11 0.66267
RMP1 LCD1 0.60389
RMP1 PGA3 0.58135
RMP1 MAS1 0.57812
RMP1 YOL166C 0.56565
RMP1 PRP2 0.56119
RMP1 CAK1 0.55725
RMP1 SEC10 0.55329
RMP1 TYS1 0.55169
RMP1 MEF1 0.54684

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YLR145W

Other databases:

Visit YLR145W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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