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Yeast Fitness

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YLR117C / CLF1

Section 1: Phenotypes.
Gene-drug relationships for YLR117C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR117C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CLF1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 4.56827 0.0030057
5-fluorouracil 38.5 uM 4.46189 0.00019669
no drug minimal media 0 4.12289 0.0045741
no drug minimal media 0 3.89293 0.0057454
5-fluorouracil 19.2 uM 3.0894 0.0035172
no drug minimal media 0 3.03199 0.014508
no drug minimal media 0 2.83671 0.018193
alizarin 66 uM 2.76173 0.0047223
methotrexate 500 uM 2.5793 0.00735
paraquat 2000 uM 2.52603 0.0083412

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YLR117C

Top 10 functional gene interactors with YLR117C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with CLF1 by heterozygous co-sensitivity:

Query Interactor Correlation
CLF1 YER139C 0.7816
CLF1 BMS1 0.77177
CLF1 IPL1 0.76164
CLF1 HUT1 0.74777
CLF1 PDH1 0.74524
CLF1 MND2 0.74004
CLF1 JIP4_p 0.73311
CLF1 YLR124W 0.73283
CLF1 EFT1 0.73173
CLF1 TGS1 0.73065

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YLR117C

Other databases:

Visit YLR117C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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