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Yeast Fitness

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YLR105C / SEN2

Section 1: Phenotypes.
Gene-drug relationships for YLR105C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR105C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SEN2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorouracil 38.5 uM 3.05702 0.0037637
5-fluorouracil 19.2 uM 1.91209 0.03697
floxuridine 3.37 uM 1.86766 0.040118
fenpropimorph 1.65 nM 1.6288 0.082142
tunicamycin 0.15 uM 1.25247 0.13289
yp glycerol 0 1.23037 0.13664
benomyl 3.4 uM 1.07101 0.16656
5-fluorouracil 38.5 uM 0.937081 0.19587
benomyl 2.4 uM 0.780708 0.22319
miconazole 50 nM 0.508678 0.31631

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YLR105C

Top 10 functional gene interactors with YLR105C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

[No heterozygous results.]
Homozygous co-fitness interactions

[No homozygous results.]

External information about YLR105C

Other databases:

Visit YLR105C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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