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Yeast Fitness
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YLR075W / RPL10



Section 1: Phenotypes.
Gene-drug relationships for YLR075W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR075W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPL10 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorouracil 38.5 uM 3.71057 0.00094974
5-fluorouracil 19.2 uM 3.10435 0.0034088
floxuridine 3.37 uM 2.54658 0.010776
ID 630688 250 uM 1.97835 0.028276
5-fluorouracil 38.4 uM 1.97629 0.028398
methotrexate 500 uM 1.96846 0.028865
chemdiv 246 62 uM 1.84704 0.037003
k2cr2o7 6.25 uM 1.68563 0.050798
chemical diversity labs 3f2 12.5 uM 1.66646 0.052691
ID 621889 125 uM 1.62977 0.056478

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YLR075W

Top 10 functional gene interactors with YLR075W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPL10 by heterozygous co-sensitivity:

Query Interactor Correlation
RPL10 PHO81 0.57655
RPL10 YPT32 0.54096
RPL10 YGL015C 0.53762
RPL10 YLR168C 0.48539
RPL10 TPO5 0.46211
RPL10 COX18 0.41746
RPL10 VID30 0.41024
RPL10 ERG7 0.40673
RPL10 YJL163C 0.40656
RPL10 ADH1 0.39487

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YLR075W

Other databases:

Visit YLR075W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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