Retrieving results for YLR061W, please wait...

Yeast Fitness
Database

Quick Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  
Advanced search

YLR061W / RPL22A



Section 1: Phenotypes.
Gene-drug relationships for YLR061W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR061W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPL22A Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
hexestrol 125 uM 4.66484 1.2934e-05
methoxsalen 500 uM 3.93819 0.00013524
trichlormethine 500 uM 3.84221 0.00018231
clotrimazole 1 uM 3.69886 0.00028312
fenpropimorph 0.4 nM 3.30091 0.00092251
leucovorin 500 uM 2.98581 0.0022401
nimustine 1000 uM 2.93077 0.0026031
chemdiv 246 62 uM 2.82841 0.0040035
caspofungin 50 nM 2.79387 0.0037567
cycloheximide 100 uM 2.75847 0.0047603

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPL22A Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 15.3364 4.4445e-12
rapamycin 9 nM 15.175 0.0021572
licl 100 mM 9.41405 1.1216e-08
latrunculin 0.78 uM 4.56404 0.022402
5-fluorouracil 19.2 uM 2.82826 0.0057971
latrunculin 0.78 uM 2.55703 0.0099032
rapamycin 9 nM 2.13431 0.061255
cantharidin 100 uM 2.12272 0.023953
minimal media 0 1.68542 0.055087
latrunculin 0.78 uM 1.61044 0.06235

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLR061W

Top 10 functional gene interactors with YLR061W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPL22A by heterozygous co-sensitivity:

Query Interactor Correlation
RPL22A RPL20A 0.61982
RPL22A RPL43A 0.59978
RPL22A RPP1A 0.59536
RPL22A RPL34A 0.58928
RPL22A RPL23B 0.58694
RPL22A RPL35B 0.58291
RPL22A RPL6B 0.5815
RPL22A RPL5 0.58006
RPL22A BUD28 0.57939
RPL22A RPL19A 0.57502

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YLR061W

Other databases:

Visit YLR061W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


Download a plain text version of this page.