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Yeast Fitness
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YLR058C / SHM2



Section 1: Phenotypes.
Gene-drug relationships for YLR058C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLR058C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SHM2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
alverine citrate 500 uM 9.57587 0.0053651
caspofungin 10 nM 7.73033 3.2427e-10
caspofungin 10 nM 7.46277 8.1693e-10
fluconazole 31.25 uM 6.38401 3.5217e-08
lapachol 500 uM 5.91111 1.834e-07
methotrexate 500 uM 5.812 2.5884e-07
caspofungin 10 nM 4.84984 6.9752e-06
itraconazole 8.8 uM 4.76292 9.3307e-06
fluconazole 130.6 uM 4.62735 1.4646e-05
caffeine 2000 uM 4.53715 1.9726e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SHM2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 36.0802 0.00038365
synthetic complete for BY4743 0 32.4571 2.6081e-07
synthetic complete for BY4743 0 31.7897 2.8924e-07
synthetic complete for BY4743 0 31.6551 0.00049823
synthetic complete for BY4743 0 31.1077 4.5823e-09
synthetic complete for BY4743 0 30.2301 3.9757e-05
synthetic complete for BY4743 0 26.4314 0.00071417
synthetic complete for BY4743 0 26.157 1.5273e-08
synthetic complete for BY4743 0 25.4918 1.826e-08
minimal media 0 23.438 2.2644e-10

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLR058C

Top 10 functional gene interactors with YLR058C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SHM2 by heterozygous co-sensitivity:

Query Interactor Correlation
SHM2 GIC1 0.54003
SHM2 PSK1 0.52213
SHM2 CPR2 0.50771
SHM2 YIL092W 0.506
SHM2 SAP185 0.49759
SHM2 ERP5 0.49483
SHM2 SHG1 0.4785
SHM2 PLB2 0.47543
SHM2 YHR113W 0.47221
SHM2 YML002W 0.46828

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SHM2 by homozygous co-sensitivity:

Query Interactor Correlation
SHM2 PHA2 0.5185
SHM2 SER1 0.50603
SHM2 ARG5,6 0.49869
SHM2 MET6 0.47678
SHM2 LCB4 0.47325
SHM2 SER2 0.46931
SHM2 ECM17 0.46793
SHM2 MET16 0.45605
SHM2 ADE3 0.45529
SHM2 MET13 0.45207

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YLR058C

Other databases:

Visit YLR058C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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