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Yeast Fitness
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YLL042C / ATG10



Section 1: Phenotypes.
Gene-drug relationships for YLL042C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLL042C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ATG10 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 15.8522 1.6635e-11
miconazole 25 nM 8.64185 1.5902e-11
5-fluorocytosine 15.6 uM 4.3319 3.8571e-05
clotrimazole 1 uM 4.26733 4.7526e-05
mycophenolic acid 500 uM 3.58554 0.00039885
miconazole 0.2 uM 3.06947 0.001778
hexetidine 31.25 uM 3.06028 0.001824
itraconazole 8.8 uM 2.99915 0.0021596
trichlormethine 1000 uM 2.86407 0.0031162
hexetidine 15.6 uM 2.70682 0.0047196

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ATG10 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 3.59956 0.00050161
zncl2 1875 uM 3.01753 0.0024011
ph4 8 2.58842 0.0070424
ph4 8 2.4014 0.010973
thiabendazole 250 uM 2.03783 0.025931
synthetic complete for BY4743 400 uM 2.03416 0.03466
paraquat 5000 uM 1.98053 0.027891
mycophenolic acid 125 uM 1.96872 0.029866
synthetic complete for BY4743 0 1.94831 0.039986
k2cr2o7 125 uM 1.93305 0.030797

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLL042C

Top 10 functional gene interactors with YLL042C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ATG10 by heterozygous co-sensitivity:

Query Interactor Correlation
ATG10 COS1 0.59564
ATG10 LAT1 0.48779
ATG10 BIT61 0.48476
ATG10 GUT1 0.47588
ATG10 DDI3 0.47316
ATG10 YCL023C 0.4568
ATG10 YOR022C 0.45172
ATG10 MNS1 0.44941
ATG10 MNT3 0.44649
ATG10 XPT1 0.43847

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ATG10 by homozygous co-sensitivity:

Query Interactor Correlation
ATG10 YOR289W 0.67897
ATG10 UIP3 0.66128
ATG10 PMA2 0.65672
ATG10 FMP41 0.6486
ATG10 SUE1 0.64272
ATG10 YDR107C 0.64156
ATG10 ENB1 0.62036
ATG10 ATG2 0.61194
ATG10 AHA1 0.59924
ATG10 YCL006C_d 0.59814

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YLL042C

Other databases:

Visit YLL042C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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