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Yeast Fitness
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YLL039C / UBI4



Section 1: Phenotypes.
Gene-drug relationships for YLL039C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLL039C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for UBI4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 7.27953 9.2241e-07
fenpropimorph 4.7 uM 5.48367 8.0614e-07
paraquat 2000 uM 5.39019 3.1917e-06
itraconazole 17.7 uM 5.13046 2.7022e-06
telomerase inhibitor ix (Biomol) 500 uM 5.10854 7.2465e-06
paraquat 2000 uM 4.95309 1.1387e-05
paraquat 2000 uM 4.95091 1.1459e-05
resveratrol 2000 uM 4.87887 1.4124e-05
itraconazole 4.4 uM 4.78054 8.7973e-06
methotrexate 125 uM 4.77914 8.8386e-06

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for UBI4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
k2cr2o7 125 uM 28.8701 < 1e-12
mitomycin c 1000 uM 14.8124 < 1e-12
latrunculin 0.78 uM 13.7148 0.0026372
latrunculin 3 uM 11.9056 2.8651e-10
latrunculin 0.78 uM 8.50415 5.0771e-08
latrunculin 0.78 uM 8.35738 0.0070085
psoralen 0.5 uM 7.86365 1.5639e-07
hgcl2 62.5 uM 7.38762 7.2542e-09
cadmium chloride 7.81 uM 7.19689 1.2596e-08
licl 100 mM 7.144 5.9046e-07

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLL039C

Top 10 functional gene interactors with YLL039C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with UBI4 by heterozygous co-sensitivity:

Query Interactor Correlation
UBI4 NTG1 0.31869
UBI4 YPR118W 0.3102
UBI4 SPS1 0.30333
UBI4 UIP3 0.29873
UBI4 SPP382 0.29834
UBI4 MDL2 0.29469
UBI4 TOF2 0.29291
UBI4 YLL047W 0.2926
UBI4 ERF2 0.2912
UBI4 YDL237W 0.29041

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with UBI4 by homozygous co-sensitivity:

Query Interactor Correlation
UBI4 DOA1 0.53985
UBI4 UBP6 0.5383
UBI4 UME1 0.50908
UBI4 FTR1 0.50033
UBI4 DID2 0.498
UBI4 GRX3 0.49557
UBI4 MRS4 0.48983
UBI4 RMD11 0.4838
UBI4 YPL182C 0.47318
UBI4 YMR057C 0.47022

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None




External information about YLL039C

Other databases:

Visit YLL039C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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